GlycoFlux™ Human ALDOC Overexpression Glycoengineered Cell (CAT#: GLJF-0925-JF5)

Description	GlycoFlux™ human ALDOC overexpression glycoengineered cell is a stable cell line that boosts aldolase C, a brain-enriched glycolytic isozyme. It provides a platform for neuro-metabolic investigations of glycan remodeling (e.g., sialylation of neuronal surface proteins), region-specific isozyme comparisons (ALDOA vs ALDOC) on glycoprotein trafficking, and lactate-shuttle paradigms that influence neuronal glycoprotein stability and synaptic receptor glycosylation.
Product Type	Overexpression Cell Lines
Cell Line	As requested by the client.

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ALDOC
Full Name	Aldolase, Fructose-Bisphosphate C
Alternative Name	ALDC
Location	17q11.2
Gene ID	230
Summary	This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.