GlycoFlux™ Human FUCA1 Overexpression Glycoengineered Cell (CAT#: GLJF-0925-JF166)

Description	GlycoFlux™ human FUCA1 overexpression glycoengineered cell is a stable cell line that constitutively overexpresses FUCA1, the lysosomal α-L-fucosidase responsible for degrading fucosylated glycoconjugates. Elevated FUCA1 enhances intracellular defucosylation and glycan recycling. This model supports fucosidosis pathway research, studies of lysosomal flux impacting cell-surface epitopes, and testing of small-molecule chaperones/inhibitors.
Product Type	Overexpression Cell Lines
Cell Line	As requested by the client.

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	FUCA1
Full Name	Alpha-L-fucosidase 1
Alternative Name	Fucosidase alpha 1; Fucosidase alpha-L 1; Alpha-L-fucosidase
Location	1p36.11
Gene ID	2517
Summary	Lysosomal enzyme responsible for degrading fucose-containing glycoproteins and glycolipids; mutations cause fucosidosis (FUCA1D), a lysosomal storage disorder.