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GlycoFlux™ Human FUT8 Overexpression Glycoengineered Cell

CAT#: GLJF-0925-JF175

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human FUT8 overexpression glycoengineered cell is a stable cell line that constitutively overexpresses FUT8, the core α1,6-fucosyltransferase for complex N-glycans. Increased core fucosylation modulates receptor signaling and IgG-FcγRIIIa engagement. Applications include ADCC tuning controls, receptor-ligand affinity studies, and process development where core-fucose content impacts efficacy or PK.
Product Type
Overexpression Cell Lines
Cell Line
As requested by the client.
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
FUT8
Full Name
Fucosyltransferase 8
Alternative Name
Alpha-1;6-fucosyltransferase; Fucosyltransferase FucT-VII; FucT-VII
Location
14q23.3
Gene ID
2530
Summary
Transfers fucose to N-linked type complex glycopeptides, distinct from other fucosyltransferases with different linkage specificities.
For Research Use Only.
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