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GlycoFlux™ Human GYS1 Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF640

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human GYS1 overexpression HepG2 cell line is a stable cell line engineered to express glycogen synthase 1 (GYS1), the muscle isoform that elongates glycogen chains through α-1,4-glycosidic linkage formation. Mutations in GYS1 are associated with muscle glycogen storage disease and exercise intolerance. This model provides a platform for studying glycogen biosynthesis, muscle energy metabolism, and therapeutic strategies targeting glycogen storage disorders.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
GYS1
Full Name
Glycogen Synthase 1
Alternative Name
GSY; GYS
Location
19q13.33
Gene ID
2997
Summary
This gene encodes an enzyme that elongates glycogen chains by forming alpha-1,4-glycosidic linkages. Mutations are linked to muscle glycogen storage disease.
For Research Use Only.
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