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GlycoFlux™ Human POMC Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF672

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human POMC overexpression HepG2 cell line is a stable glycoengineered line that constitutively overexpresses pro-opiomelanocortin, a prohormone processed into multiple bioactive peptides. In hepatocytes, it serves as a tractable secretory-cargo probe to test how glycan environment, propeptide trafficking, and convertase access influence peptide maturation, secretion efficiency, and receptor-pathway cross-talk.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
POMC
Full Name
Proopiomelanocortin
Alternative Name
LPH; MSH; NPP; POC; ACTH; CLIP; OBAIRH
Location
2p23.3
Gene ID
5443
Summary
The gene product is a large precursor that undergoes selective cleavage depending on tissue type, yielding up to ten active peptides. These include ACTH and beta-lipotropin in the pituitary, and other peptides in different tissues that affect pigmentation, pain modulation, metabolism, and immune response. Mutations associate with obesity, adrenal insufficiency, and red hair.
For Research Use Only.
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