GlycoFlux™ Human SLC2A4 Overexpression HEK293 Cell Line (CAT#: GLJF-0925-JF482)

Description	GlycoFlux™ human SLC2A4 overexpression HEK293 cell line is a stable cell line engineered for enhanced expression of GLUT4 (SLC2A4), an insulin-regulated glucose transporter central to energy uptake in adipose and muscle tissues. Normally sequestered intracellularly, GLUT4 rapidly translocates to the plasma membrane upon insulin stimulation to facilitate glucose transport. This model provides a robust platform for dissecting insulin resistance, type 2 diabetes, metabolic syndrome, and therapeutic interventions targeting glucose uptake pathways.
Product Type	Overexpression Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	qPCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & DMEM
Application	Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SLC2A4
Full Name	Solute Carrier Family 2 Member 4
Alternative Name	GLUT4
Location	17p13.1
Gene ID	6517
Summary	A member of the solute carrier 2 family, this gene encodes an insulin-responsive glucose transporter. In muscle and adipose cells, it is retained intracellularly until insulin triggers its relocation to the plasma membrane, enabling glucose uptake. Mutations have been linked to noninsulin-dependent diabetes mellitus.