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GlycoFlux™ Lenti-Human SIGLEC8 Viral Particle

CAT#: GLJF-1025-JF108

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SPECIFIC INQUIRY
Antibiotic Resistance:
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Titer:
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Specifications Quality Control Target Information Related Products
Specifications
Description
GlycoFlux™ Lenti-SIGLEC8 Viral Particle encodes SIGLEC8, a CD33-like receptor with ITIM and SLAM-like motifs and hematopoietic-restricted expression. Optimized to produce stable mammalian transductants, the vector supports exploration of eosinophil/mast-cell-relevant signaling, ligand discovery, and variant impact, with standard selection or fluorescence sorting.
Product Type
Recombinant Lentivirus
Target
SIGLEC8
Species
Human
Promotor
EF1a
Packaging System
Lentivirus
Packaging Cell
HEK293T
Application
The lentiviral vector is a powerful, HIV-based system used for gene delivery, notable for its ability to transduce both dividing and non-dividing cells (e.g., neurons, stem cells). It permanently integrates the gene into the host genome, ensuring long-term, sustained expression for applications in research and studies related to gene therapy.
Shipping
Shipped on dry ice with temperature held at or below -80°C.
Storage
Store at -80°C to maintain their titer and stability.
Handling Notes
Store products at -80°C, and avoid repeated freeze-thaw cycles to maintain viral titer. For safety, always handle the products in a biological safety cabinet, using appropriate personal protective equipment like lab coats, gloves, and eye protection.
Product Disclaimer
These products are for research use only and not for diagnostic or clinical use. The user assumes full responsibility for all safety protocols and compliance with relevant regulations. While we are committed to quality, Creative Biolabs makes no guarantee as to the performance of these products in a specific application.
Quality Control
Titer Assay
qPCR
Mycoplasma Test
Negative
Sterility
Sterility testing confirmed no microbial contamination.
Transduction Evaluation
On request, Creative Biolabs conducts in vitro or in vivo transduction assays to evaluate lentiviral delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation
All lentiviral vectors at Creative Biolabs are verified for correct proviral integration by PCR. In this assay, cells are transduced with serial dilutions of the lentiviral vector, harvested after a few days, and genomic DNA is isolated. A defined region of the expected lentiviral insert is then PCR-amplified to confirm identity.
Target Information
Full Name
Sialic Acid Binding Ig Like Lectin 8
Alternative Name
SAF2; SIGLEC-8; SIGLEC8L; Sialic Acid Binding Ig Like Lectin
Location
19q13.33-q13.41
Gene ID
27181
Summary
SIGLECs, including SIGLEC8, are type I transmembrane proteins with unique expression patterns, mainly in hematopoietic cells. SIGLEC8, a member of the CD33-like subgroup, is localized to the 19q13.3-q13.4 region and features two conserved cytoplasmic motifs: an immunoreceptor tyrosine-based inhibitory motif (ITIM) and a SLAM-like motif that interacts with the SLAM-associated protein (SAP).
For Research Use Only.
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