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GlycoFlux™ MMLV-Human GCK Viral Particle (CAT#: GLJF-1025-JF425)

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SPECIFIC INQUIRY
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Description GlycoFlux™ MMLV-GCK Viral Particle introduces GCK (glucokinase), a liver/β-cell hexokinase not inhibited by G6P that gates glucose sensing; the system builds stable models for insulin secretion, hepatic uptake, and diabetes/hypoglycemia variants.
Product Type Recombinant MMLV Retrovirus
Target GCK
Species Human
Promotor MMLV 5' LTR promoter
Packaging System Retrovirus
Packaging Cell HEK293T
Application This MMLV vector is a common retroviral vector system that permanently integrates a gene into the host cell's genome, allowing for long-term, sustained expression. It is a popular tool for gene manipulation in dividing cells and for generating iPS cells in biomedical research.
Shipping Shipped on dry ice with temperature held at or below -80°C.
Storage Store at -80°C to maintain their titer and stability.
Handling Notes Store products at -80°C, and avoid repeated freeze-thaw cycles to maintain viral titer. For safety, always handle the products in a biological safety cabinet, using appropriate personal protective equipment like lab coats, gloves, and eye protection.
Product Disclaimer These products are for research use only and not for diagnostic or clinical use. The user assumes full responsibility for all safety protocols and compliance with relevant regulations. While we are committed to quality, Creative Biolabs makes no guarantee as to the performance of these products in a specific application.
Titer Assay qPCR
Mycoplasma Test Negative
Sterility Sterility testing confirmed no microbial contamination.
Transduction Evaluation On request, Creative Biolabs conducts in vitro or in vivo transduction assays to evaluate lentiviral delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation Creative Biolabs verifies all retroviral vectors by a PCR-based proviral integration check. In brief, cells are transduced with serial dilutions of the retroviral preparation and, after several days, genomic DNA is extracted. A predefined segment of the expected retroviral insert is then amplified by PCR to confirm correct identity and integration.
Full Name Glucokinase
Alternative Name GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; PNDM1; FGQTL3
Location 7p13
Gene ID 2645
Summary This gene encodes a hexokinase that phosphorylates glucose to glucose-6-phosphate, a key step in glucose metabolism. Unlike other hexokinases, this enzyme is not inhibited by glucose-6-phosphate. It plays a role in insulin secretion in the pancreas and glucose uptake in the liver. Mutations are linked to diabetes and hypoglycemia.
For Research Use Only.
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