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GlycoFlux™ MSCV-Human SIGLEC5 Viral Particle (CAT#: GLJF-1025-JF619)

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Description GlycoFlux™ MSCV-SIGLEC5 Viral Particle implements Murine Stem Cell Virus (MSCV) delivery of SIGLEC5, a CD33-related inhibitory lectin on monocytes, macrophages, and neutrophils; permanent integration in dividing myeloid progenitors underpins immune-evasion and GBS-interaction studies.
Product Type Recombinant MSCV Retrovirus
Target SIGLEC5
Species Human
Promotor MSCV 5' LTR promoter
Packaging System Retrovirus
Packaging Cell HEK293T
Application This MSCV vector is a common retroviral vector system used to achieve high-efficiency, stable gene delivery into target cells, such as hematopoietic stem cells. It ensures long-term, sustained expression by stably integrating the gene into the host cell's genome.
Shipping Dispatched on dry ice with temperature held at or below -80°C.
Storage Store at -80°C to preserve titer and stability.
Handling Notes Store at -80°C and avoid repeated freeze-thaw cycles to preserve viral titer. For safety, handle materials in a biological safety cabinet while wearing appropriate PPE (lab coat, gloves, and eye protection).
Product Disclaimer These products are for research use only and not for diagnostic or clinical use. The user assumes full responsibility for all safety protocols and compliance with relevant regulations. While we are committed to quality, Creative Biolabs makes no guarantee as to the performance of these products in a specific application.
Titer Assay qPCR
Mycoplasma Test Negative
Sterility Sterility testing confirmed no microbial contamination.
Transduction Evaluation Creative Biolabs offers, upon request, in vitro and in vivo transduction assays to verify lentiviral targeting and to quantify transgene expression and functional output.
Insert Identity Confirmation All Creative Biolabs retroviral vectors undergo PCR-based verification of proviral integration. Cells are transduced across a dilution series of the retroviral preparation; after several days, genomic DNA is isolated, and a defined region of the expected insert is PCR-amplified to confirm correct identity and integration.
Full Name Sialic Acid Binding Ig Like Lectin 5
Alternative Name CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5; Sialic Acid Binding Ig Like Lectin
Location 19q13.41
Gene ID 8778
Summary This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, characterized by structural motifs in the immunoglobulin-like domains and sialic acid recognition sites in the first Ig V-set domain. The encoded protein is part of the CD33-related Siglec subgroup and inhibits the activation of monocytes, macrophages, and neutrophils. It also plays a role in immune evasion by Group B Streptococcus (GBS).
For Research Use Only.
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