Ionizable lipid 244-Cis

244-Cis is a novel ionizable lipid designed to enhance mRNA potency and safety, making it suitable for repeated dosing. LNPs formulated with 244-Cis enable highly efficient mRNA delivery and translation in fibrotic lungs without inducing immunogenicity. This advantage allows for the potential of repeated doses of mRNA for protein replacement therapy in lung diseases, an application where the need for low toxicity and safety is critical.

2956402-64-3

[(Z)-Non-2-enyl] 9-[4-[2-[bis[9-[(Z)-non-2-enoxy]-9-oxononyl]amino]ethyl]piperazin-1-yl]nonanoate; 244cis; PD205992; HY-160552

C₆₀H₁₁₁N₃O₆

970.56

InChI=1S/C60H111N3O6/c1-4-7-10-13-22-31-40-55-67-58(64)43-34-25-16-19-28-37-46-61(47-38-29-20-17-26-35-44-59(65)68-56-41-32-23-14-11-8-5-2)49-52-63-53-50-62(51-54-63)48-39-30-21-18-27-36-45-60(66)69-57-42-33-24-15-12-9-6-3/h31-33,40-42H,4-30,34-39,43-57H2,1-3H3/b40-31-,41-32-,42-33-

LLTJKESWTCPZGG-IHTYGJSSSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.