Ionizable lipid C12-200

C12-200 is a well-established and highly effective ionizable lipid used as a foundational component in the assembly of lipid nanoparticles (LNPs). These LNPs serve as advanced non-viral vectors for the delivery of therapeutic nucleic acids, including short interfering RNA (siRNA), messenger RNA (mRNA), and self-amplifying RNA (saRNA) to various cell types and animal models. C12-200-based LNPs are noted for their high in vivo potency at low doses and have been successfully applied to achieve placental delivery in pregnant mouse models, making them an important reference standard in nucleic acid delivery research.

1220890-25-4

1-[2-[Bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol; 1,1'-((2-(4-(2-((2-(Bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol); MFCD32062847

C₇₀H₁₄₅N₅O₅

1136.9

MFCD32062847

InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3

RVHYPUORVDKRTM-UHFFFAOYSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.