Ionizable lipid CKK-E12

CKK-E12 is a multi-tailed, ionizable lipid designed for the optimized delivery of RNA-based therapeutics via lipid nanoparticles (LNPs). This compound exhibits high potency at very low doses and is highly selective for transfecting liver parenchymal cells in vivo, while showing minimal off-target activity in the heart, lung, and kidney. It is frequently employed as a positive control lipid for benchmarking LNP efficacy and tissue targeting.

1432494-65-9

3,6-Bis[4-[bis(2-hydroxydodecyl)amino]butyl]piperazine-2,5-dione; SCHEMBL14906247; EN300-27749265; CYH-270

C₆₀H₁₂₀N₄O₆

993.64

InChI=1S/C60H120N4O6/c1-5-9-13-17-21-25-29-33-41-53(65)49-63(50-54(66)42-34-30-26-22-18-14-10-6-2)47-39-37-45-57-59(69)62-58(60(70)61-57)46-38-40-48-64(51-55(67)43-35-31-27-23-19-15-11-7-3)52-56(68)44-36-32-28-24-20-16-12-8-4/h53-58,65-68H,5-52H2,1-4H3,(H,61,70)(H,62,69)

ZISVTYVLWSZJAL-UHFFFAOYSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.