Ionizable lipid DLin-MC3-DMA

DLin-MC3-DMA is a clinically significant ionizable lipid component essential for forming lipid nanoparticles (LNPs). It is utilized in formulations for the delivery of both small interfering RNA (siRNA) and plasmid DNA (pDNA) into cells. MC3-based LNPs have successfully demonstrated gene silencing effects, such as delivering siRNA to reduce Factor VII levels in mouse models. Furthermore, this lipid has been employed in the study of therapeutic delivery to leukemic cells, specifically a BCR-ABL siRNA model used in chronic myeloid leukemia (CML) research.

1224606-06-7

DLIN-M-C3-DMA; [(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate; UNII-Q0J6FQ6FKP; Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester; Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate

C₄₃H₇₉NO₂

642.1

MFCD31657426

InChI=1S/C43H79NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-42(46-43(45)40-37-41-44(3)4)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,42H,5-12,17-18,23-41H2,1-4H3/b15-13-,16-14-,21-19-,22-20-

NRLNQCOGCKAESA-KWXKLSQISA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.