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LNP lipid-8 is an ionizable, single-tail, multi-head lipid used to form lipid nanoparticles (LNPs). LNP compositions have demonstrated effectiveness as transport vehicles for various biologically active substances, including small molecule drugs, proteins, and nucleic acids, into cells and intracellular compartments. LNP lipid-8 is particularly adept at delivering siRNA to T cells, displaying high selectivity over other cell types like hepatocytes.