MPEG-DSPE

MPEG-DSPE is a biocompatible amphiphilic conjugate consisting of poly(ethylene glycol) (PEG) tethered to the phospholipid 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE). The PEG moiety is terminally blocked with a methoxy group (MPEG). This molecule is the primary constituent used to create "stealth" liposomes and LNPs. The hydrophilic PEG brush border enhances the stability of the lipid bilayer, prevents opsonization, and dramatically prolongs the circulation time of the nanocarriers in the bloodstream, which is critical for systemic drug delivery applications.

124011-52-5

DSPG (18:0/18:0 PG); sodium;2,3-dihydroxypropyl 2,3-di(octadecanoyloxy)propyl phosphate; 1,2-Distearoyl-sn-glycero-3-phospho-rac-glycerol sodium salt; DSPG-Na; sodium [(2R)-2,3-bis(1-oxooctadecoxy)propyl] 2,3-dihydroxypropyl phosphate

C₄₂H₈₂NaO₁₀P

801.1

InChI=1S/C42H83O10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h39-40,43-44H,3-38H2,1-2H3,(H,47,48);/q;+1/p-1

YNQYZBDRJZVSJE-UHFFFAOYSA-M

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.