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The primary endogenous molecular species of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), featuring an 18:0 (stearoyl) chain at the sn-1 position and a 20:4 (arachidonoyl) chain at the sn-2 position. As the most abundant phosphatidylinositol in the plasma membrane, PI(4,5)P2 governs critical cellular functions, serving as both a substrate for phospholipase C-mediated signaling and a crucial membrane anchor for numerous proteins that regulate the cell cortex and ion channel activity.