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Phosphatidylinositol 5-phosphate (PI(5)P) is a low-abundance signaling lipid, and the dioctanoyl (DiC8) derivative is a synthetic, purified analog used for research. PI(5)P plays a critical role in cellular communication and is implicated in regulating the cytoskeleton, endocytosis, and nuclear function. It is known to bind the PHD finger of the nuclear adapter protein ING2.