PI(3,4,5)P3, diC16

Phosphoinositides (PIPs) are minor components of cellular membranes yet function as fundamental signaling intermediaries. Phosphatidylinositol 3,4,5-trisphosphate (PIP3) results from the PI 3-kinase-mediated phosphorylation of PI(4,5)P2 and initiates numerous signaling cascades that control cell growth, survival, proliferation, protein synthesis, and glucose uptake. Elevated PIP3 levels resulting from aberrant PI 3-K activity are strongly associated with inflammatory diseases and various cancers. PIP3 is subsequently dephosphorylated by phosphatases, including PTEN and SHIP. This is a synthetic, purified dipalmitoyl form of PI(3,4,5)P3.

165689-82-7

Dipalmitoyl phosphatidylinositol 3,4,5-trisphosphate; PtdIns(3,4,5)P3 C16; PI(3,4,5)P3 C16; PIP3; D-myo-phosphatidylinositol 3,4,5-trisphosphate

C₄₁H₇₅Na₇O₂₂P₄

1,204.84

InChI=1S/C41H82O22P4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)57-31-33(59-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-58-67(55,56)63-38-36(44)39(60-64(46,47)48)41(62-66(52,53)54)40(37(38)45)61-65(49,50)51/h33,36-41,44-45H,3-32H2,1-2H3,(H,55,56)(H2,46,47,48)(H2,49,50,51)(H2,52,53,54)/t33-,36+,37+,38?,39-,40+,41?/m1/s1

ZSZXYWFCIKKZBTZVDPZPSOSAN

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.