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Recombinant Canine Uromodulin (UMOD) protein [His-Tag], E. coli

CAT#: GP01-126J

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Specifications Target Information Related Products
Specifications
Product Overview
Recombinant Canine Uromodulin (UMOD) protein (Arg32-Glu151) was expressed in E. coli with a His-Tag at the N-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Biological Activity
Determined by its binding ability in a functional ELISA.
Source
E. coli
Species
Canine
Fragment
Arg32-Glu151
Sequence
MGHHHHHHSGSRSCSECHSNATCMEDGMVTTCSCLVGFTGSGFECVDLDECAIPGAHNCSEGSSCMNTLGSYLCTCPDGFRLTPGLGCIDVDECSEPGLSRCHALATCINNKGNYSCVCPAGYRGDGQHCE
Tag
His-Tag at the N-terminus
Predicted MW
13.8 KDa
Purity
>95%, determined by SDS-PAGE and HPLC
Endotoxin Level
<1 EU/μg, determined by the LAL method
Conjugation
Unconjugated
Target Information
Target
UMOD
Full Name
Uromodulin
Uniprot ID
Q862Z3
Background
This protein functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Alternate Names
Tamm-Horsfall urinary glycoprotein; THP; UMOD; Uromodulin
For Research Use Only.
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