Recombinant HIV-2 subtype A (isolate Ghana-1) Envelope glycoprotein gp160 (ENV), E. coli (CAT#: GPX-177-E-J)

Product Overview	Recombinant HIV-2 subtype A (isolate Ghana-1) Envelope glycoprotein gp160 was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	E. coli
Species	HIV-2 subtype A (isolate Ghana-1)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	ENV
Full Name	Envelope glycoprotein gp160
Uniprot ID	P18040
Background	The envelope glycoprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface. The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.
Alternate Names	Envelope glycoprotein gp160; Env polyprotein; Surface protein gp120; SU; Glycoprotein 120; gp120; Transmembrane protein gp41; TM; Glycoprotein 41; gp41