Recombinant Human C4A Protein, Glycoengineered Human Cell Lines

Recombinant Human C4A protein (NP_001002029.3) is produced in Glycoengineered Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with human post-translational modifications.

Glycoengineered Human Cell Lines

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

C4A

Complement C4-A

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.

Complement Component 4A (Rodgers Blood Group); C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 2; Acidic Complement C4; CPAMD2; CO4; Complement Component 4A; Rodgers Form Of C4; C4A Anaphylatoxin; EC 2.1.1.144; Acidic C4; EC 2.7.11; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; C4; RG