Recombinant Human CCL5 Protein, Sia-Adjusted Human Cell Lines (CAT#: GLJF-0722-JF848)

Product Overview	Recombinant Human CCL5 protein (NP_002976.2) is produced in Sia-Adjusted Human Cell Lines. This expression system is used for the production of glycoproteins and antibodies with different sialylation degree.
Source	Sia-Adjusted Human Cell Lines
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	CCL5
Full Name	C-C motif chemokine 5
Gene ID	6352
Uniprot ID	P13501
Accession Number	NP_002976.2
Background	This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Alternate Names	Chemokine (C-C Motif) Ligand 5; SIS-Delta 2; Eosinophil Chemotactic Cytokine; T-Cell Specific Protein P288; Beta-Chemokine RANTES; D17S136E; TCP228; SCYA5; EoCP; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5; Small Inducible Cytokine Subfamily A (Cys-Cys); Small Inducible Cytokine A5 (RANTES); T-Cell Specific RANTES Protein; T-Cell-Specific Protein RANTES; T Cell-Specific Protein P228; Small-Inducible Cytokine A5; Regulated Upon Activation; And Presumably Secreted; Normally T-Expressed; Member 5; RANTES; SISd