Recombinant Human CFH Protein, Sia-Increased Human Cell Lines

Recombinant Human CFH protein (NP_000177.2) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.

Sia-Increased Human Cell Lines

Human

His-tag, FC-tag

>90%, determined by SDS-PAGE.

Regular batch

None

CFH

Complement factor H

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor 2 (Complement); H Factor 1 (Complement); Beta-1H; HF1; HF2; HF; Adrenomedullin Binding Protein; Beta-1-H-Globulin; Factor H-Like 1; H Factor 1; Factor H; CFHL3; AHUS1; AMBP1; ARMD4; ARMS1; FHL1; HUS; FH