Recombinant Human coronavirus HKU1 (isolate N2) Hemagglutinin-esterase (HE) (12-385 aa) [His-tag], E. coli (CAT#: GP02-058J)

Product Overview	Recombinant Human coronavirus HKU1 (isolate N2) Hemagglutinin-esterase (12-385 aa) was expressed in E. coli with a 10xHis-tag at the N-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Source	E. coli
Species	Human coronavirus HKU1 (isolate N2)
Fragment	12-385 aa
Sequence	YGFNEPLNVVSHLNHDWFLFGDSRSDCNHINNLKIKNYGYLDIHPSLCNNGKISSSAGDSIFKSYHFTRFYNYTGEGDQIIFYEGVNFNPHHRFKCFFNGSNDVWIFNKVRFYRALYSNMALFRYLTFVDILYNFSFSIKANICNSNILSLNNPIFISTNYSKDVYFTLSGCSLYLVPLCLFKSNFSQYYYNMDTGFAYGYSNFVSSDLDCTYISLKPGSYKIFSTGFVLSIPTKALCFNKSKQFVPVQVVDSRWNNLRASDTSLSDACQLPYCYFRNSSGNYVGKYDINHGDNGFTSILSGLLYNVSCISYYGSFLYDNFTSIWPRFSFGNCPTSAYIKLNCFYDPLPIILQGILLFLALLFIVFLLFLVYHG
Tag	10xHis-tag at the N-terminus
Predicted MW	45.9 kDa
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	HE
Full Name	Hemagglutinin-esterase
Uniprot ID	Q14EB1
Background	This protein is a structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.
Alternate Names	HE protein; E3 glycoprotein; HE; 2b