Recombinant Human CST6 Protein, Sia-Increased Human Cell Lines (CAT#: GLJF-0722-JF770)

Product Overview	Recombinant Human CST6 protein (NP_001314.1) is produced in Sia-Increased Human Cell Lines. This expression system is used for the production of glycoproteins with high sialylation and core fucosylation.
Source	Sia-Increased Human Cell Lines
Species	Human
Tag	His-tag, FC-tag
Purity	>90%, determined by SDS-PAGE.
Endotoxin Level	Regular batch
Conjugation	None

Target	CST6
Full Name	Cystatin-M
Gene ID	1474
Uniprot ID	Q15828
Accession Number	NP_001314.1
Background	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.
Alternate Names	Cystatin E/M; Cystatin-6; Cystatin-E; Cysteine Proteinase Inhibitor; Cystatin M/E; Cystatin 6; Cystatin M