Recombinant Human Glycoprotein Ib platelet subunit beta (GP1BB) (26-206 aa) [His-SUMO/Myc-Tag], E. coli

Recombinant Human Glycoprotein Ib platelet subunit beta (NP_000398.1) (26-206 aa) was expressed in E. coli with a 10xHis-SUMO-tag at the N-terminus and a a Myc-tag at the C-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.

Human

26-206 aa

CPAPCSCAGTLVDCGRRGLTWASLPTAFPVDTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAEDELRAACAPGPLCWGALAAQLALLGLGLLHALLLVLLLCRLRRLRARARARAAARLSLTDPLVAERAGTDES

10xHis-SUMO-tag at the N-terminus and Myc-tag at the C-terminus

39.3 kDa

>90%, determined by SDS-PAGE.

Unconjugated

GP1BB

Glycoprotein Ib platelet subunit beta

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain.

BS; CD42C; GPIBB; BDPLT1; GPIbbeta