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Recombinant Human GZMB protein (NP_004122.2) is produced in Fuco-Adjusted Human Cell Line. This expression system is used for the production of glycoproteins and antibodies with different fucosylation degrees.
The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing.