Recombinant Human Major histocompatibility complex, class ii, dr alpha (HLA-DRA) (26-254 aa) [His-Tag], E. coli (CAT#: GP02-059J)

Product Overview	Recombinant Human Major histocompatibility complex, class ii, dr alpha (NP_061984.2) (26-254 aa) was expressed in E. coli with a 6xHis-tag at the N-terminus. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Source	E. coli
Species	Human
Fragment	26-254 aa
Sequence	IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGVRKSNAAERRGPL
Tag	6xHis-tag at the N-terminus
Predicted MW	30.0 kDa
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	HLA-DRA
Full Name	Major histocompatibility complex, class ii, dr alpha
Uniprot ID	P01903
Accession Number	NP_061984.2
Background	HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Alternate Names	HLA-DRA1