0
Inquiry Basket

There is no product in the shopping cart, buy it!

Recombinant Human Major histocompatibility complex, class ii, dr beta 1 (HLA-DRB1) [His-Tag or Tag-free], Yeast (CAT#: GP02-061J)

Datasheet
SizeQtyAdd To Basket
Inquiry

Product Overview Recombinant Human Major histocompatibility complex, class ii, dr beta 1 (NP_002115.2) was expressed in Yeast with a His-tag at the N-terminus or Tag-free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Source Yeast
Species Human
Tag His-tag at the N-terminus or Tag-free
Purity >90%, determined by SDS-PAGE.
Conjugation Unconjugated
Target HLA-DRB1
Full Name Major histocompatibility complex, class ii, dr beta 1
Uniprot ID P01911
Accession Number NP_002115.2
Background HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.
Alternate Names SS1; DRB1; HLA-DRB; HLA-DR1B
For Research Use Only.
Online Inquiry
Creative Biolabs-Glycoprotein Follow us on
  • ()
    ()
    ()
ISO 9001 Certified - Creative Biolabs Quality Management System.