Recombinant Mouse C-type lectin domain family 7 member a (CLEC7A) protein, NS0 cell line (CAT#: GP01-042J)

Product Overview	Recombinant Mouse C-type lectin domain family 7 member a (CLEC7A) protein was expressed in NS0 cell line. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	NS0 cell line
Species	Mouse
Purity	>95%, determined by SDS-PAGE and HPLC
Conjugation	Unconjugated

Target	CLEC7A
Full Name	C-type lectin domain family 7 member a
Uniprot ID	Q6QLQ4
Background	This protein functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (PubMed:27288407). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.
Alternate Names	Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1; CLEC7A; C-type lectin domain family 7 member a