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Recombinant Rabies virus (RABV) (strain Pasteur vaccins / PV) Glycoprotein (G) (20-524 aa), E. coli

CAT#: GPX04-367J

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Specifications Target Information Related Products
Specifications
Product Overview
Recombinant Rabies virus (RABV) (strain Pasteur vaccins/ PV) Glycoprotein (NP_056796.1) (20-524 aa) was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity
Determined by its binding ability in a functional ELISA.
Source
E. coli
Species
Rabies virus (RABV) (strain Pasteur vaccins / PV)
Fragment
20-524 aa
Sequence
KFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYMELKVGYISAIKMNGFT CTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYH WLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPGGNCSGVAVSSTYCSTNHDYTIWMP ENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTW VAMQTSNETKWCPPGQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRR LSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLRVGGRCHPHVNGVFF NGIILGPDGNVLIPEMQSSLLQQHMELLVSSVIPLMHPLADPSTVFKNGDEAEDFVEVHL PDVHERISGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCWRRVNRSEPTQHNLRGTGRE VSVTPQSGKIISSWESYKSGGETGL
Tag
His-tag or Tag free
Purity
>90%, determined by SDS-PAGE.
Conjugation
Unconjugated
Target Information
Target
G
Full Name
Glycoprotein
Gene ID
1489856
Uniprot ID
P08667
Accession Number
NP_056796.1
Background
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
Alternate Names
Glycoprotein
For Research Use Only.
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