Introduction of GNRHR
The gonadotropin-releasing hormone receptor (GNRHR) is a receptor protein encoded by gene GNRHR. This receptor is a member of the G-protein coupled receptor (GPCR) family and expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary and prostate. It can promote the release of a gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) by binding with GNRHR.
|Basic Information of GNRHR|
|Protein Name||Gonadotropin-releasing hormone receptor|
|Aliases||GnRH-R, GRHR, LHRHR, LRHR|
|Organism||Homo sapiens (Human)|
Function of GNRHR Membrane Protein
GNRHR is a receptor for the gonadotropin-releasing hormone. It is the central point of the hypothalamus secretion produced and secreted by the combination of hypothalamic GnRH and pituitary gonadotropin in mammals. The combination of GNRHR and GnRH results in the dissociation of receptor-related heterogeneous dimer G protein and the initiation of several intracellular signaling cascades and causes extracellular and intracellular calcium fluxes, several MAPK pathways of activation, including those that lead to ERK1 activation and C-jun N-terminal kinase (JNK) pathways.
Application of GNRHR Membrane Protein in Literature
This article reports that endogenous GnRH acts on GnRHR neurons and triggers burst to fire in these cells during late proestrus and estrus.
The article demonstrates that the GnRH-GnRHR system is not required for growth or exercise/sensory/directional behavior for the first month prior to the onset of puberty. However, the lack of the GnRH-GnRHR axis results in a decrease in the weight of the female subcutaneous inguinal fat pad and an increase in glucose and may result in insulin resistance.
The article demonstrates that the first direct interaction partner of GnRHR is SET, which is helpful for the conversion of GnRHR signaling to the cAMP pathway.
This article shows that the GnRHR expression is very low in gastric cancer, and the loss of GnRHR expression could be a poor prognostic factor, which implied that GnRHR could play an important role in the development of gastric cancer.
This article assesses the aberrant expression of the gonadotropin-releasing hormone receptor (GnRHR) in human adrenal tissue, including aldosterone-producing adenomas (APA). And the ectopic expression of GnRH through its receptor may be a potential regulator of CYP11B2 expression levels in certain APA cases.
GNRHR Preparation Options
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