Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Gonadotropin releasing hormone receptor |
| Gene Name | GNRHR |
| Uniprot | P30968 (Human); Q01776 (Mouse) |
| Synonym | HH7; GRHR; LRHR; LHRHR; GNRHR1; gonadotropin-releasing hormone receptor; gnRH receptor; gnRH-R; gonadotropin-releasing hormone (type 1) receptor 1; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; luliberin receptor; type I GnRH receptor |
| Background | The gonadotropin-releasing hormone receptor (GNRHR) is a receptor protein encoded by gene GNRHR. This receptor is a member of the G-protein coupled receptor (GPCR) family and expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary and prostate. It can promote the release of a gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) by binding with GNRHR. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX402 | NativeExtract™ Human GNRHR Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3336K | MemDX™ Membrane Protein Human GNRHR Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0423X | MemDX™ Membrane Protein Human GNRHR (Gonadotropin releasing hormone receptor) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX510 | MemDX™ Membrane Protein Human GNRHR (1-38aa) Expressed in HEK293, C-Human Fc tag | HEK293 cell | Partial | N/A |
| Please for more products or customization | ||||
R***y: Their team delivered a high-yield, endotoxin-free GNRHR variant within 3 weeks.
16/Oct/2023
S***er: Responsive technical support and detailed characterization reports streamlined our functional analysis workflows.
22/Aug/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Cryo-EM-Guided Vector Design for Receptor Activation
Creative Biolabs offers Cryo-EM-guided vector design services. Advancements in cryogenic electron microscopy (cryo-EM) have enabled high-resolution structural analysis of GNRHR in complex with endogenous ligands and signaling partners. For instance, recent studies resolved the "inverted U-shaped" binding conformation of GnRH within the receptor's orthosteric pocket, highlighting conserved residues critical for ligand recognition and Gq protein coupling. Leveraging these insights, adeno-associated virus (AAV) vectors can be engineered to deliver gene-editing tools or synthetic GnRH analogs with enhanced stability. Such vectors may correct receptor misregulation in hormone-dependent cancers or infertility by restoring physiological signaling cascades.
Correction of Pathogenic Variants
Creative Biolabs offers correction of pathogenic variants services. Genome editing offers precision in rectifying mutations linked to aberrant GNRHR activity. For example, splice-site variants associated with central precocious puberty can be repaired ex vivo using ribonucleoprotein complexes delivered via lipid nanoparticles. This approach leverages structural data on GnRH-GNRHR interactions to avoid off-target effects. Creative Biolabs' proprietary genotyping platforms facilitate patient stratification by identifying actionable genetic variants, thereby enabling tailored editing strategies.
Creative Biolabs offers comprehensive and innovative services to drive the development of GNRHR cell therapy. Please for more services.
CAR-T Cell Engineering for Hormone-Driven Cancers
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting GNRHR-overexpressing malignancies, such as prostate or breast cancer, exploit receptor density as a discriminative marker. Preclinical models demonstrate that CAR-T cells armed with GnRH antagonist domains selectively eliminate tumor cells while sparing healthy tissues. Creative Biolabs' immunofluorescence imaging services provide critical validation of CAR-T targeting specificity through subcellular receptor localization analysis.
Stem Cell-Derived Secretory Platforms for Hormone Replacement
Creative Biolabs offers stem cell-derived secretory services. Induced pluripotent stem cells (iPSCs) differentiated into hypothalamic neurons can be programmed to secrete pulsatile GnRH, mimicking physiological hormone release. This method addresses deficiencies in conditions like hypogonadotropic hypogonadism by restoring HPG axis function. Optimization of secretion kinetics relies on Creative Biolabs' gene expression profiling, which identifies transcriptional regulators of GnRH biosynthesis.
The integration of structural biology, gene editing, and cellular engineering opens unprecedented opportunities in GNRHR-targeted drug development. Creative Biolabs' expertise in viral vector design, gene-editing validation, and high-resolution imaging positions us as your ideal partner for accelerating preclinical breakthroughs. to explore customized solutions for your pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
