Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsThe gonadotropin-releasing hormone (GnRH) receptor, also known as the luteinizing hormone releasing hormone (LHRH) receptor. It is a receptor of G-protein coupled receptor (GPCR) family, which has seven transmembranes. GnRH receptor, with a weight of a 60 kDa, is found primarily in the pituitary and is responsible for triggering the release of GnRH from the hypothalamus. There is evidence of the presence of GnRH and its receptors in extra-pituitary tissues as well as a role in the progression of certain cancers. GnRH receptor is expressed on the surface of pituitary gonadal cells and lymphocytes. It is also expressed on the cells of prostate, breasts and ovaries.
Fig.1 GnRH receptor signaling networks. (Perrett, 2013)
GnRH regulates reproduction by binding and activating GnRH receptors on pituitary gonadotrope cells, which synthesize and secrete the LH, FSH, and gonadotropins. The gonadotropins act on the gonads to stimulate gametogenesis, gonadal cell proliferation, and gonadal steroids production. GnRH secretion is inhibited during childhood. It increases during puberty when increased production of gonadotropins and gonadal steroids triggers sexual development. Destruction of GnRH receptor function disrupts the replication and mutation of the GnRH receptor gene. GnRHR disrupts or delays pubertal development and leads to congenital hypogonadotropic hypogonadism.
There are two major GnRH receptors in humans, including GNRHR and GNRHR2, which are encoded by GNRHR and GNRHR2, respectively.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please do not hesitate to contact us for more information.
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