Introduction of GPR1
GPR1 is a protein that in humans is encoded by the GPR1 gene, also called G-protein coupled receptor 1. It is a member of the G protein-coupled receptor family of transmembrane receptors. GPR1 functions as a receptor for chemerin. Chemerin is an 18 KD non-biologically active complex protein called chemerin precursor (prochemerin) whose cleavage of the C-terminal part by an extracellular serine protease and can be converted to a chemerin protein with a high bioactivity of 16 KD.
|Basic Information of GPR1|
|Protein Name||G-protein coupled receptor 1|
|Aliases||GPCR6, PAGH2, PITA2|
|Organism||Homo sapiens (Human)|
Function of GPR1 Membrane Protein
GPR1 was associated with adipose differentiation. Silencing GPR1 gene significantly reduced lipid accumulation and inhibited C/EBPα and PPARγ mRNA expression as well as FABP4 and inflammatory cytokines TNF-α and IL-6 mRNA expression. It was suggested that in the process of 3T3-L1 preadipocyte differentiation, on the one hand, GPR1 may interfere with the expression of C/EBPα, thereby affecting the activation of downstream PPARγ and FABP4, resulting in inhibition of adipocyte differentiation. On the other hand, GPR1 may inhibit inflammatory cytokines. In addition, the expression of TNF-α and IL-6 mRNA enhances the sensitivity of TNF-α and insulin, thereby improving the metabolic disturbance caused by TNF-α and insulin resistance, reducing the accumulation of lipids in adipocytes, and inhibiting the differentiation of adipocytes.
Application of GPR1 in Literature
This article reports that FAM19A is a novel regulator of neural stem cell proliferation and differentiation, and the effect of FAM19A on NSC function is mediated by GPCR, which is likely to play an important role in brain development and neurogenesis through a mechanism.
This article reveals that the improvement in steroid synthesis in mice are highly harmonized with DHEA which is due to GPR1 deficiency, so a therapeutic target for GHEA-induced androgen excess may be GPR1.
This paper shows that the mice show glucose intolerance after knocking out the GPR1 gene and chemerin receptors are related to cardiovascular disease, cancer, steroidogenesis, human immunodeficiency virus replication, and neurogenesis.
The article shows that chemerin can increase blood pressure and cause high blood pressure and it acts on CMKLR1 but does not work with GPR1.
This article shows that phosphorylation of ERK1/2 MAP kinase and internalization of two receptors is due to the combination of chemerin and CMKLR1 and GPR1.
GPR1 Preparation Options
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