Introduction of GPR37
GPR37, also known as endothelin B receptor-like protein 1 or parkin-associated endothelin receptor-like receptor, is a protein encoded by the human GPR37 gene. It is a member of the G protein-coupled receptor family which contains seven transmembrane domains and is found in the cell and endoplasmic reticulum membranes. During the past years, studies have reported that GPR37 could interact with Parkin and is involved in juvenile Parkinson disease.
|Basic Information of GPR37|
|Protein Name||Prosaposin receptor GPR37|
|Aliases||Endothelin B receptor-like protein 1, ETBR-LP-1, G-protein coupled receptor 37, Parkin-associated endothelin receptor-like receptor, PAELR|
|Organism||Homo sapiens (Human)|
Function of GPR37 Membrane Protein
GPR37 is a member of the G protein-coupled receptor (GPCR) family. Studies have shown that GPR37 is widely expressed in diverse human tissues, which including but not limited to spinal cord, placenta, liver, stomach, and testis. Particular, it is highly expressed in brain regions such as corpus callosum, caudate nucleus, putamen, substantia nigra, hippocampus and cerebellum. As a parkin-associated endothelin-like receptor, GPR37 is reported to be associated with autosomal recessive juvenile Parkinson’s disease. GPR37 could interact with HSPA1A and Parkin (ligase). Moreover, GPR37 is involved in the development of autosomal-recessive juvenile parkinsonism as well as major depressive and bipolar disorders. And the level of GPR37 is significantly increased in patients with AR-JP which indicates that the aggregation of GPR37 is linked to disease pathogenesis. In addition, overexpression of GPR37 in the nigrostriatal region of rats resulted in pathologic changes common to Parkinson’s disease.
Fig.1 GPR37 folding and its role in cell fate. (Smith, 2015)
Application of GPR37 Membrane Protein in Literature
This article reveals that loss of GPR37 alters oligodendrocyte physiology and increases susceptibility to demyelination, indicating that GPR37 could be a potential drug target for the treatment of demyelinating diseases such as multiple sclerosis.
This report suggests that GPR37 plays a key role in controlling A2AR biology in the striatum, which may be relevant for PD management.
This article focuses on the multiple roles of GPR37 with relevance to potential disease modification and symptomatic therapies of Parkinson disease (PD) and highlights unsolved issues in this field.
This article investigates the role of GPR37 in the control of cocaine-mediated electrophysiological effects (synaptic transmission and short-term plasticity) in corticostriatal synapses. It indicates that GPR37 is involved in the cocaine-induced modification of basal synaptic transmission without modifying cocaine effects in short-term plasticity.
This article reveals that REG4 could promote peritoneal metastasis of gastric cancer through GPR37 and trigger a positive feedback loop.
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