Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | G protein-coupled receptor class C group 5 member B |
| Gene Name | GPRC5B |
| Uniprot | Q9NZH0 (Human); Q923Z0 (Mouse) |
| Synonym | RAIG2; RAIG-2; G-protein coupled receptor family C group 5 member B; G protein-coupled receptor, family C, group 1, member B; retinoic acid responsive gene protein; retinoic acid-induced gene 2 protein |
| Background | G-protein coupled receptor family C group 5 member B (GPRC5B) is a protein encoded by the GPRC5B gene. This protein is one of the defined CPRC5 receptors (the others are GPRC5A, GPRC5C, GPRC5D), which are classified as family C G protein-coupled receptors (GPCRs). GPRC5 receptors share approximately 30-40% sequence homology to each other and 25% homology to the other family C members. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. Analysis of the protein sequence reveals that CPRC5B contains short extracellular amino-terminal domains (ATDs). Moreover, this receptor undergoes alternative splicing and produces multiple transcript variants. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX225 | NativeExtract™ Human GPRC5B Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3493K | MemDX™ Membrane Protein Human GPRC5B Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0481X | MemDX™ Membrane Protein Human GPRC5B (G protein-coupled receptor class C group 5 member B) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| S01YF-0423-KX588 | MemDX™ Membrane Protein Human GPRC5B (33-56aa) Expressed in HEK293, C-Mouse Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
B***se: Ideal for receptor-ligand studies.
12/Jun/2023
R**y: Their team delivered a truncated GPRC5B variant with rapid turnaround.
06/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene editing services. Precise manipulation of GPRC5B expression or function can be achieved through gene editing. This approach enables targeted knockout, knock-in, or allelic correction of GPRC5B loci, particularly in preclinical models of metabolic disorders where its dysregulation contributes to insulin resistance. For example, studies leveraging homology-directed repair strategies have successfully introduced disease-relevant point mutations into GPRC5B orthologs, recapitulating human metabolic phenotypes in vivo. Creative Biolabs' validated libraries ensure minimal off-target effects, making this a robust platform for functional validation and therapeutic exploration.
Creative Biolabs offers AAV vector-driven GPRC5B overexpression services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters—such as liver- or adipose-targeted capsids—allow localized GPRC5B overexpression to counteract its pathological underexpression. In murine models of non-alcoholic fatty liver disease (NAFLD), intrahepatic delivery of AAV9-GPRC5B constructs has restored lipid homeostasis and attenuated hepatic steatosis. Creative Biolabs' proprietary AAV serotype screening platforms optimize tropism and transduction efficiency, enabling researchers to tailor delivery systems for organ-specific therapeutic outcomes.
Creative Biolabs offers RNA interference services. In cancers marked by GPRC5B overexpression, lipid nanoparticle-encapsulated siRNA or shRNA constructs can suppress oncogenic signaling. For instance, in vitro studies using GPRC5B-targeting siRNA in pancreatic adenocarcinoma cell lines have demonstrated reduced tumor cell invasion and chemoresistance. Creative Biolabs' endosomal escape-enhancing formulations maximize cytoplasmic siRNA delivery, ensuring potent and sustained target suppression.
Creative Biolabs offers comprehensive and innovative services to drive the development of GPRC5B cell therapy. Please for more services.
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells engineered to recognize GPRC5B surface epitopes show promise in targeting malignancies with aberrant receptor expression. Preclinical data in glioblastoma models reveal that GPRC5B-directed CAR-T cells penetrate the blood-brain barrier and selectively lyse tumor-initiating cells while sparing normal neural tissues. Creative Biolabs' lentiviral vector-based CAR construct design services include safety switches and co-stimulatory domain optimization, minimizing cytokine release syndrome risks.
Creative Biolabs offers iPSC differentiation guided by GPRC5B signaling services. GPRC5B's role in adipocyte differentiation makes it a critical regulator for iPSC-derived therapies. Creative Biolabs' iPSC differentiation protocols ensure reproducibility, accelerating translational applications.
Creative Biolabs offers ex vivo gene-edited immune cells development services. GPRC5B-negative regulatory T cells (Tregs), edited ex vivo using base-editing platforms, exhibit enhanced suppressive activity in autoimmune inflammation models. Transient electroporation of mRNA encoding GPRC5B-specific zinc finger nucleases enables precise gene disruption without genomic integration risks. Creative Biolabs' clinical-grade electroporation systems and Treg expansion kits support scalable manufacturing of these therapeutic cells.
The molecular complexity of GPRC5B demands cutting-edge tools and strategic insights. Creative Biolabs' end-to-end services streamline therapeutic development, reducing timelines and technical risks. to discuss how our tailored gene editing, viral vector, and cell engineering solutions can advance your GPRC5B-targeted pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
