Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | G protein-coupled receptor class C group 5 member C |
| Gene Name | GPRC5C |
| Uniprot | Q9NQ84 (Human); Q8K3J9 (Mouse) |
| Synonym | RAIG3; RAIG-3; G-protein coupled receptor family C group 5 member C; orphan G-protein coupled receptor; retinoic acid responsive gene protein; retinoic acid-induced gene 3 protein |
| Background | G-protein coupled receptor family C group 5 member C (GPRC5C) is a protein that in humans is encoded by the GPRC5C gene. GPRC5C protein is a member of the GPRC5 receptors, which are identified as a subfamily of the type 3 G protein-coupled receptor (GPCR) family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. Other members of type 3 GPCR family include metabotropic glutamate receptors, GABAB receptors, calcium-sensing receptors, and pheromone receptors. However, in contrast to these receptors, the sequence analysis of GPRC5C has shown that this receptor has only short N-terminal domains. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX224 | NativeExtract™ Human GPRC5C Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3551K | MemDX™ Membrane Protein Human GPRC5C Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0482X | MemDX™ Membrane Protein Human GPRC5C (G protein-coupled receptor class C group 5 member C) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| S01YF-0423-KX589 | MemDX™ Membrane Protein Human GPRC5C (27-50aa) Expressed in HEK293, C-Mouse Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
El***or: Technical support resolved batch-specific queries promptly.
16/Nov/2023
Th***ore: Critical for our interaction mapping—highly recommend tailored services.
25/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers targeted editing services. Genome engineering enables precise knock-in or knock-out of GPRC5C coding or regulatory sequences, facilitating functional studies and therapeutic interventions. For instance, base editing systems have been leveraged to correct oncogenic missense mutations in GPRC5C-linked pathways, restoring receptor signaling homeostasis in preclinical cancer models. Creative Biolabs' customized RNA design and delivery optimization services ensure robust editing efficiency, particularly in challenging primary cell systems. Such approaches are invaluable for validating GPRC5C's role in disease progression and identifying druggable allelic variants.
Creative Biolabs offers AAV vector-driven GPRC5C overexpression services. Adeno-associated virus (AAV) vectors engineered with tissue-specific promoters enable targeted GPRC5C overexpression in metabolic tissues, such as pancreatic β-cells or adipose depots. Preclinical studies demonstrate that hepatic GPRC5C upregulation enhances insulin sensitivity in murine models of type 2 diabetes, suggesting therapeutic potential. Creative Biolabs' proprietary AAV serotype library ensures optimal tropism for in vivo delivery, while RNA sequencing validates transgene specificity.
Creative Biolabs offers comprehensive and innovative services to drive the development of GPRC5C cell therapy. Please for more services.
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting GPRC5C surface epitopes show promise in solid tumors, where the receptor is overexpressed in malignancy. Our team has developed scFv domains derived from high-affinity monoclonal antibodies, enabling precise recognition of GPRC5C conformational epitopes. Coupled with 4th-generation co-stimulatory signaling domains, these CAR-T constructs exhibit enhanced tumor infiltration and cytotoxicity in glioblastoma xenografts. Creative Biolabs' immunofluorescence-based efficacy profiling provides spatial resolution of CAR-T activity within tumor microenvironments.
Creative Biolabs offers stem cell-derived GPRC5C agonist delivery systems development services. Induced pluripotent stem cells (iPSCs) differentiated into GPRC5C-expressing secretory progenitors serve as sustainable platforms for localized paracrine therapy. In osteoarthritis models, synovial iPSC grafts engineered to secrete GPRC5C ligands reduce cartilage degradation by modulating inflammatory cytokine cascades. Creative Biolabs' imaging workflows, utilizing lattice light-sheet microscopy, enable real-time tracking of stem cell engraftment and ligand release dynamics.
The complexity of GPRC5C's signaling networks demands expertise in both gene and cell therapy modalities. Creative Biolabs' cross-disciplinary teams offer unparalleled support in vector design, gene-editing optimization, and functional validation—critical for de-risking therapeutic development. For a comprehensive evaluation of your GPRC5C program's feasibility, to schedule a consultation with our specialists. Explore our proprietary tools and data-driven strategies to transform preclinical insights into clinical candidates.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
