Introduction of GPRC5C
G-protein coupled receptor family C group 5 member C (GPRC5C) is a protein that in humans is encoded by the GPRC5C gene. GPRC5C protein is a member of the GPRC5 receptors, which are identified as a subfamily of the type 3 G protein-coupled receptor (GPCR) family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. Other members of type 3 GPCR family include metabotropic glutamate receptors, GABAB receptors, calcium-sensing receptors, and pheromone receptors. However, in contrast to these receptors, the sequence analysis of GPRC5C has shown that this receptor has only short N-terminal domains.
|Basic Information of GPRC5C|
|Protein Name||G-protein coupled family C group 5 member C|
|Organism||Homo sapiens (Human)|
Functions of GPRC5C Membrane Protein
GPRC5Cs are found in peripheral tissues, such as the stomach, pancreas, kidneys, and liver. Moreover, it has been found to be developmentally regulated and differentially distributed in the brain. It has been suggested that this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. As a potential therapeutic target for different diseases, antagonists of this receptor remain to be developed for the prevention or treatment of different diseases. Currently, a comprehensive study of the structure and specific functions of this protein remains to be established.
Applications of GPRC5C Membrane Protein in Literature
This article investigated the distribution, expression, and the sequence information of the GPRC5C protein, which was identified as a member of retinoic acid-inducible receptors.
This article studied the functions of GPRC5C in the GPRC5C-deficient mice and found that the expression of this receptor is developmentally regulated and differentially distributed in the brain. However, it does not affect the animal behavior.
This article investigated the renal localization and physiologic parameters of GPRC5C in the GPRC5C-deficient mice. The results implied that GPRC5C modulated the renal contribution to systemic pH homeostasis.
This article found that pancreatic islets expressed high levels of GPRC5C and the agents activating GPRC5C may be a promising modality to treat or prevent diabetes by restoring and/or maintaining functional beta cell mass.
GPRC5C Preparation Options
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