Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 1 |
| Gene Name | GRM1 |
| Uniprot | Q13255 (Human); P97772 (Mouse) |
| Synonym | MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; glutamate receptor, metabotropic 1; protein phosphatase 1, regulatory subunit 85 |
| Background | The metabotropic glutamate receptor 1 (also known as mGluR1, GRM1) is a member of the group I metabotropic glutamate receptors (mGluRs), which are family C G-protein coupled receptors that participate in the modulation of synaptic transmission and neuronal excitability throughout the central nervous system. Like other mGluRs, this receptor has a large extracellular domain, which binds to the glutamate and mediates cell signal transduction. GRM1 is widely expressed in the neurons and taste buds. The activation of GRM1 can result in phospholipase C stimulation, adenylyl cyclase stimulation, and adenosine monophosphate (MAP) kinase phosphorylation. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX191 | NativeExtract™ Human GRM1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| Please for more products or customization | ||||
A***n: Highly recommended for signaling studies.
17/Mar/2023
A**m: The custom GRM1 service delivered a His-tagged protein in 4 weeks with rigorous QC.
19/Oct/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers transcriptional modulation services. Recent advances in gene editing systems have enabled precise transcriptional regulation of GRM1, a key antagonist in the TGF-β/BMP signaling cascade. Creative Biolabs' proprietary gene-editing platforms facilitate in vitro and in vivo validation of these constructs, ensuring scalable therapeutic development. Clients exploring fibrosis or neuroregeneration strategies may benefit from consulting our team to optimize guide RNA design and delivery systems tailored to their specific experimental needs.
Creative Biolabs offers AAV-driven delivery services. Recombinant adeno-associated virus (AAV) vectors engineered with short hairpin RNA (shRNA) against GRM1 mRNA offer a potent modality to attenuate its BMP-inhibitory activity. Preclinical studies demonstrate that intra-articular AAV-shRNA delivery significantly reduces GRM1 levels in osteoarthritis models, mitigating cartilage degradation by rebalancing BMP-2/4 signaling. Creative Biolabs' expertise in viral vector tropism optimization ensures targeted transduction of chondrocytes or synoviocytes, enhancing therapeutic precision. Interested clients are encouraged to inquire about our validated AAV serotypes and in vivo efficacy assessment protocols.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM1 cell therapy. Please for more services.
Creative Biolabs offers GRM1-specific CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting GRM1-overexpressing malignancies, such as glioblastoma or pancreatic cancer, exploit its aberrant extracellular signaling. Early-stage in vitro data reveal that GRM1-directed CAR-T cells exhibit potent cytotoxicity against tumor spheroids while sparing healthy tissues, likely due to GRM1's limited expression in normal adults. Creative Biolabs provides end-to-end CAR-T development services, including antigen-binding domain design and functional validation in 3D tumor models. Collaborative opportunities exist for clients seeking to advance this approach into translational studies.
Creative Biolabs offers MSCs engineered with GRM1 antagonists development services. MSCs modified to secrete GRM1-neutralizing proteins (e.g., monoclonal antibodies or soluble receptors) show promise in reprogramming fibrotic microenvironments. For example, MSC-derived GRM1 inhibitors counteract BMP suppression in pulmonary fibrosis models, promoting alveolar epithelial repair. Leveraging Creative Biolabs' MSC engineering platforms, researchers can rapidly prototype and test such therapies using patient-derived iPSCs or primary cells. We invite potential collaborators to schedule a consultation to explore customized cell-line development and preclinical testing frameworks.
Our multidisciplinary expertise in gene editing, viral vector design, and cell engineering positions Creative Biolabs as an indispensable partner for GRM1-focused drug development. to discuss your project requirements, access cutting-edge platforms, or request a customized proposal.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
