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HighlightsIntroduction of GRM2
GRM2 (mGluR2) is one of the group II metabotropic glutamate receptors (mGluRs), which are coupled to Gi/o. mGluRs belong to the family C of the G-protein coupled receptors (GPCRs) and act to modulate neuronal excitability and synaptic transmission in many brain regions. Like other mGluRs, GRM2 is composed of two main domains, including a large extracellular domain and a 7 transmembrane region. The large extracellular domain is termed the Venus Flytrap domain, which contains the glutamate-binding site. In terms of signaling pathways, GRM2 is involved in signaling pathways including inhibition of adenylyl cyclase, activation of K+ channels, and inhibition of Ca++ channels.
| Basic Information of GRM2 | |
| Protein Name | Metabotropic glutamate receptor 2 |
| Gene Name | GRM2 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q14416 |
| Transmembrane Times | 7 |
| Length (aa) | 872 |
| Sequence |
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL |
Functions of GRM2 Membrane Protein
In humans, GRM2 is only expressed in the brain including neurons and astrocytes. GRM2 is predominantly localized at the periphery of the presynaptic terminal. GRM2-deficient mice had been used to study the functions of this receptor. These animals showed normal regulation of basal synaptic transmission and long-term potentiation (LTD) but were severely impaired in terms of LTD induced by low-frequency stimulation at this synapse. In other studies, GRM2 activation was suggested to result in cognitive impairment and had been implicated in addiction to drugs of abuse. As a result, antagonists of this receptor have been considered promising candidates for the treatment of anxiety and other brain disorders.
Applications of GRM2 Membrane Protein in Literature
This article demonstrated that mGluR2/3 was a promising target in the search for smoking cessation medication.
This article investigated the mechanisms for mGluR2/3 agonists against N-methyl-D-aspartate receptor (NMDAR) hypofunction. Results showed that early interventions with mGluR2/3 agonists prevented Schizophrenia-like electrophysiological, morphological, and cognitive deficits in adults via restoring NMDAR signaling during a critical postnatal period.
This article investigated the effects of mGluR2/3 agonist, LY379268, on the extinction and reinstatement of morphine-induced conditioning place preference. LY379268 agonist seemed to be a potential role in the drug-seeking behaviors.
This article demonstrated that a selective mGluR2/3 agonist was effective in reducing the severity of diabetic neuropathy.
This article demonstrated that the soluble extracellular domain of neuroligin 1 functionally interacted with mGluR2 and thereby decreasing synaptic strength.
GRM2 Preparation Options
The isolation of native and functional membrane proteins plays a critical role in their academic research and drug discovery. As an expert in this field, Creative Biolabs provides our esteemed clients with the rapid, high quality, and cost-effective membrane protein production services. For more information please see Magic™ Membrane Protein Production Service. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GRM2 antibody development services.
Creative Biolabs is dedicated to partnering with you to address your research requirements, understand your purpose, discuss with you about the possibilities, design and optimize the preparation strategies, and work side-by-side with you through your research projects. Contact us and experience the great value of our membrane protein preparation services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
