Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 2 |
| Gene Name | GRM2 |
| Uniprot | Q14416 (Human); Q14BI2 (Mouse) |
| Synonym | GLUR2; mGlu2; GPRC1B; MGLUR2; glutamate receptor homolog; glutamate receptor, metabotropic 2 |
| Background | GRM2 (mGluR2) is one of the group II metabotropic glutamate receptors (mGluRs), which are coupled to Gi/o. mGluRs belong to the family C of the G-protein coupled receptors (GPCRs) and act to modulate neuronal excitability and synaptic transmission in many brain regions. Like other mGluRs, GRM2 is composed of two main domains, including a large extracellular domain and a 7 transmembrane region. The large extracellular domain is termed the Venus Flytrap domain, which contains the glutamate-binding site. In terms of signaling pathways, GRM2 is involved in signaling pathways including inhibition of adenylyl cyclase, activation of K+ channels, and inhibition of Ca2+ channels. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX361 | NativeExtract™ Human GRM1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP0495X | MemDX™ Membrane Protein Human GRM2 (Glutamate metabotropic receptor 2) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| MPX0041K | MemDX™ Membrane Protein Human GRM2 for Antibody Discovery, Partial (20-498aa) | Partial | N/A | |
| Please for more products or customization | ||||
Ch***es: Reliable data reproducibility and excellent technical support streamlined our neuropharmacology research.
03/Jun/2023
D***el: Turnaround time exceeded expectations, accelerating our drug discovery pipeline without compromising quality.
22/Aug/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers allelic correction services. Precision genome editing offers a transformative approach to rectify GRM2 mutations implicated in synaptic dysfunction. For instance, studies demonstrate that GRM2 knockdown in hippocampal neurons disrupts dendritic arborization, highlighting its role in neuronal maturation. Gene editing systems can restore wild-type GRM2 expression in models of epilepsy or Alzheimer's disease, where GRM2 dysregulation exacerbates neurodegeneration. Creative Biolabs' optimized RNA design and delivery platforms ensure allele-specific targeting, minimizing off-site effects.
Creative Biolabs offers AAV-mediated GRM2 overexpression services. Adeno-associated virus (AAV) vectors engineered with cell-specific promoters enable spatially controlled GRM2 overexpression in vulnerable neuronal populations. Research using RNA-scope and qRT-PCR reveals GRM2 expression gradients between mature and newborn hippocampal neurons. AAV9-based delivery of GRM2 cDNA into the dentate gyrus could reverse synaptic deficits in Alzheimer's models, leveraging Creative Biolabs' proprietary capsid engineering for enhanced blood-brain barrier penetration.
Creative Biolabs offers RNA interference services. In conditions like epilepsy, siRNA or shRNA delivered via lipid nanoparticles can suppress pathologically elevated GRM2 activity. This approach mimics experimental knockdown models, where reduced GRM2 impairs dendritic complexity. Creative Biolabs' bioengineered siRNA libraries and in vivo validation pipelines streamline the identification of candidates with optimal silencing efficacy and minimal immunogenicity.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM2 cell therapy. Please for more services.
Creative Biolabs offers GRM2-expressing iPSC-derived neurons development services. Induced pluripotent stem cells (iPSCs) differentiated into GRM2-high hippocampal neurons can replace degenerated cells in Alzheimer's disease. Transcriptomic profiling confirms that GRM2 expression peaks during neuronal maturation. Creative Biolabs' differentiation protocols and quality control assays ensure reproducibility in generating functionally integrated grafts.
Creative Biolabs offers GRM2-specific CAR-T cells development services. Chimeric antigen receptor (CAR) T cells targeting GRM2-positive autoreactive immune cells may mitigate neuroinflammation. While preliminary, this strategy aligns with advancements in CAR-T engineering for CNS disorders. Creative Biolabs' custom CAR construct design and cytokine release profiling mitigate risks of cytokine storm or off-target neurotoxicity.
Creative Biolabs offers ex vivo gene-modified astrocyte implant development services. Astrocytes transduced with GRM2 via lentiviral vectors can enhance synaptic support in epilepsy models. These cells, validated via immunofluorescence and RNA-scope, secrete neuroprotective factors while modulating glutamate homeostasis. Creative Biolabs' lentiviral packaging services, including tiered biosafety testing, accelerate translational readiness.
From allelic correction to AAV-driven synaptic rescue, Creative Biolabs' end-to-end solutions integrate cutting-edge molecular tools, preclinical validation, and scalable manufacturing. to explore how our gene editing, viral vector, and cell therapy platforms can de-risk your GRM2 program and expedite IND-enabling studies.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
