Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 4 |
| Gene Name | GRM4 |
| Uniprot | Q14833 (Human); Q68EF4 (Mouse) |
| Synonym | mGlu4; GPRC1D; MGLUR4; glutamate receptor, metabotropic 4 |
| Background | GRM4 (mGluR4) is encoded by the GRM4 gene localized in human chromosome 6. It is classified into group III metabotropic glutamate receptors (mGluRs) based on sequence homology, G-protein-coupling profile and ligand specificity. mGluRs are members of class C of the G-protein coupled receptors and possess a seven-transmembrane-spanning domain and an extracellular domain which contains the glutamate binding site. GRM4 is very highly expressed in the cerebellum, with lower levels of expression in the hippocampus, basal ganglia, and olfactory bulb. GRM4 is predominantly expressed presynaptically. It is commonly coupled to second messenger pathway via Gαi/o proteins that inhibit adenylylcyclase thus cAMP formation and protein kinase Aactivation in heterologous expression systems. Besides, the GRM4 receptor can also act by coupling to the Gαq protein, thus activating the phospholipase C effector system and thus excitatory events. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX189 | NativeExtract™ Human GRM4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP0497X | MemDX™ Membrane Protein Human GRM4 (Glutamate metabotropic receptor 4) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| MPX0043K | MemDX™ Membrane Protein Human GRM4 Expressed in CHO for Antibody Discovery, Partial (33-518aa) | CHO cells | Partial | N/A |
| Please for more products or customization | ||||
Ga***el: Technical support promptly addressed customization queries, ensuring seamless integration into our research workflow.
23/Aug/2023
H***y: The tailored GRM4 protein met precise specifications with rapid turnaround.
18/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers precision genome editing services. Homology-directed repair represents a transformative approach for rectifying loss-of-function mutations within the GRM4 locus. By introducing donor templates encoding wild-type sequences, this methodology enables precise correction of allelic variants linked to neurological and metabolic disorders. Preclinical validation in induced pluripotent stem cell (iPSC)-derived neuronal models has demonstrated restored metabotropic glutamate receptor signaling, underscoring its therapeutic viability. Creative Biolabs' expertise in designing high-fidelity RNA constructs ensures minimal off-target effects, a critical consideration for clinical translation.
Creative Biolabs offers AAV-mediated GRM4 overexpression services. AAV serotypes engineered for selective CNS tropism are increasingly employed to deliver GRM4 transgenes into neurons exhibiting receptor hypoactivity. For instance, intra-hippocampal administration of AAV9-GRM1/4 chimeric vectors in rodent models of cognitive dysfunction have shown enhanced synaptic plasticity and memory consolidation. This approach synergizes with Creative Biolabs' proprietary AAV capsid optimization platform, which enhances blood-brain barrier penetration while mitigating immune responses.
Creative Biolabs offers ASO modulation services. Pathogenic splice variants of GRM4 implicated in neuropsychiatric conditions can be selectively silenced using chemically modified ASOs. Recent studies utilizing locked nucleic acid (LNA)-ASOs in primate models achieved dose-dependent suppression of aberrant isoform expression, normalizing glutamate receptor density in cortical regions. Creative Biolabs offers end-to-end ASO design and in vivo validation services, enabling rapid transition from target identification to IND-enabling studies.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM4 cell therapy. Please for more services.
Creative Biolabs offers GRM4-specific CAR-T constructs services. Chimeric antigen receptor (CAR)-T cells engineered to recognize GRM4-expressing tumors demonstrate potent cytotoxicity in glioblastoma and melanoma models. Second-generation CAR designs incorporating 4-1BB co-stimulatory domains enhance persistence while reducing exhaustion markers. Creative Biolabs' lentiviral vector production services, optimized for neural antigen-targeted CARs, provide GMP-grade reagents essential for preclinical efficacy trials.
Creative Biolabs offers iPSC-derived GRM4-positive neural progenitors development services. Transplantation of GRM4-overexpressing iPSC-derived dopaminergic progenitors has shown functional engraftment in Parkinsonian models, with positron emission tomography (PET) confirming receptor reinstatement in striatal circuits. Our stem cell differentiation protocols integrate GRM4-specific fluorescent reporters, enabling real-time tracking of graft viability—a service Creative Biolabs tailors to client-specific disease models.
Creative Biolabs offers microglia for GRM4 pathway modulation services. Microglial cells edited ex vivo to upregulate GRM4 exhibit enhanced phagocytic clearance of amyloid-beta plaques in Alzheimer's models. Creative Biolabs' proprietary electroporation systems achieve >90% editing efficiency in primary microglia, a technical hurdle traditionally limiting this approach.
The intricate biology of GRM4 demands bespoke therapeutic strategies, from viral vector optimization to high-throughput screening of receptor modulators. Creative Biolabs' end-to-end platforms—spanning gene editing design, AAV engineering, and CAR-T validation—accelerate timelines while ensuring regulatory compliance. to streamline your therapeutic pipeline. Whether developing gene-editing therapies or cell-based interventions, our team delivers robust preclinical data packages tailored to meet the investor's expectations.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
