Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 6 |
| Gene Name | GRM6 |
| Uniprot | O15303 (Human); Q5NCH9 (Mouse) |
| Synonym | mGlu6; CSNB1B; GPRC1F; MGLUR6; glutamate receptor, metabotropic 6 |
| Background | Metabotropic glutamate receptors (mGluRs) belong to the family C of G-protein coupled receptors (GPCRs) which are seven-transmembrane-domain proteins that interact with G-proteins. GRM6 (mGluR6) is one of the eight defined mGluRs and it belongs to the group III subfamily receptors, which are coupled to Gi/o. Extracellularly, GRM6 has a large extracellular domain containing the binding site for its ligand, glutamate. Intracellularly, the large C-terminus can interact with different signaling systems. Three GRM6 splice variants can be generated. GRM6 is found primarily in retinal ON bipolar cells. The GRM6 subtype is expressed restrictedly at the postsynaptic site of retinal ON-bipolar cells. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX187 | NativeExtract™ Human GRM6 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| Please for more products or customization | ||||
L*o: Rigorous QC protocols ensure reliable batch-to-batch performance, ideal for ligand-binding studies and receptor signaling research.
24/Sep/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers allele correction services. GRM6 mutations are implicated in congenital stationary night blindness (CSNB), where disrupted metabotropic glutamate receptor signaling impairs retinal neurotransmission. Homology-directed repair enables precise correction of pathogenic variants in patient-derived retinal organoids. Preclinical studies demonstrate restored GRM6 expression and functional recovery of ON-bipolar cell signaling. Creative Biolabs' genotyping platforms validate allele-specific edits, ensuring fidelity for translational applications. For sponsors pursuing inherited retinal disease therapies, leveraging such precision tools may accelerate IND-enabling studies.
Creative Biolabs offers AAV-delivered gene supplementation services. Adeno-associated virus (AAV) serotypes with tropism for bipolar cells (e.g., AAV8-opsin hybrids) effectively deliver GRM6 cDNA to rescue synaptic transmission in CSNB models. Dual-promoter systems enable cell-specific expression, minimizing off-target effects in Müller glia or photoreceptors. Quantifying transgene expression via Creative Biolabs' multiplexed assays confirms target engagement, while electrophysiological readouts validate functional recovery. This approach is scalable for disorders where GRM6 haploinsufficiency drives pathology.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM6 cell therapy. Please for more services.
Creative Biolabs offers iPSC-derived bipolar neurons development services. Induced pluripotent stem cells (iPSCs) differentiated into GRM6-expressing bipolar neurons offer autologous grafts to replace defective retinal circuits. Creative Biolabs' lentiviral reporters (e.g., GRM6-driven GFP) enable real-time tracking of synaptic integration in 3D retinal organoids. Patch-clamp studies reveal grafted cells establish functional connections with photoreceptors, rescuing light-evoked responses. This platform supports both disease modeling and cell replacement therapies.
Creative Biolabs offers CAR-T cell engineering services. In glioblastoma subsets, GRM6 overexpression correlates with oncogenic glutamate release. Chimeric antigen receptor (CAR)-T cells engineered to target GRM6+ cells exhibit potent cytotoxicity in primary patient-derived xenografts. Creative Biolabs' flow cytometry panels quantify CAR-T activation and tumor cell lysis, while RNAseq identifies off-target gene dysregulation. This strategy may synergize with small-molecule GRM6 antagonists to treat refractory CNS malignancies.
Creative Biolabs provides tools and analytical services to de-risk GRM6-focused programs. Our viral vector engineering, cell omics, and high-content imaging platforms deliver the granularity needed to advance first-in-class therapies. to schedule a strategic consultation—transform your GRM6 pipeline from concept to clinic with precision.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
