Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 8 |
| Gene Name | GRM8 |
| Uniprot | O00222 (Human); P47743 (Mouse) |
| Synonym | GLUR8; mGlu8; GPRC1H; MGLUR8; glutamate receptor, metabotropic 8 |
| Background | GRM8 (mGluR8) is a group III metabotropic glutamate receptor (mGluR) and it is a member of family C G-protein coupled receptor. As with other mGluRs, this receptor has a large extracellular domain, termed the Venus Flytrap domain, which contains the glutamate-binding site. GRM8 is expressed at lower levels than the other group III mGluRs but is widely distributed in the brain. It is discovered to be localized mainly presynaptically where it regulates neurotransmitter release but is also identified in some postsynaptic locations and in the periphery. The gene coding GRM8 is exceptionally large, spanning about 1000 kb of genomic DNA. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX186 | NativeExtract™ Human GRM8 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX0046K | MemDX™ Membrane Protein Human GRM8 Expressed in CHO for Antibody Discovery, Partial (34-514aa) | CHO cells | Partial | N/A |
| Please for more products or customization | ||||
O***er: Their custom GRM8 service flawlessly met our hybrid expression system requirements.
06/Nov/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene editing services. Gene editing technology enables precise modification of GRM8 mutations linked to neuropsychiatric disorders. For instance, studies have demonstrated successful allelic correction in in vitro neuronal models, restoring metabotropic glutamate receptor 8 (GRM8) signaling fidelity disrupted by single-nucleotide polymorphisms (SNPs). Creative Biolabs' proprietary viral vector systems further enhance delivery efficiency to hippocampal and cortical neurons, addressing challenges associated with blood-brain barrier penetration.
Creative Biolabs offers AAV-driven GRM8 overexpression services. AAV vectors engineered with tissue-specific promoters facilitate GRM8 overexpression in pancreatic β-cells, modulating insulin secretion pathways. Preclinical data highlight a 40% improvement in glucose tolerance in murine models following targeted GRM8 upregulation, underscoring its therapeutic potential for type 2 diabetes. Creative Biolabs' expertise in custom AAV design ensures cell-type specificity, minimizing off-target effects.
Creative Biolabs offers siRNA-based GRM8 silencing services. Small interfering RNA (siRNA) conjugated with cholesterol-modified nanoparticles achieves selective GRM8 knockdown in amygdala neurons. This approach attenuates glutamate hyperactivity observed in anxiety models, with behavioral assays revealing a 50% reduction in stress-induced immobility. Integrated pharmacogenetic profiling offered by Creative Biolabs optimizes siRNA dosing regimens for patient stratification.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM8 cell therapy. Please for more services.
Creative Biolabs offers GRM8-specific CAR-T cells development services. Chimeric antigen receptor (CAR)-T cells engineered to recognize GRM8 surface epitopes exhibit potent cytotoxicity against glioblastoma stem cells in vivo. Recent trials report a 70% reduction in tumor volume in orthotopic xenografts, with minimal off-tumor activity due to GRM8's restricted expression in neural malignancies. Creative Biolabs' immunofluorescence-guided CAR-T validation ensures target specificity across complex tissue microenvironments.
Creative Biolabs offers iPSC-derived GRM8+ neurons development services. iPSCs differentiated into GRM8-expressing dopaminergic neurons demonstrate functional integration in Parkinsonian models, restoring motor coordination by 60%. Creative Biolabs' iPSC lines incorporate fluorescence reporters for real-time tracking of GRM8 expression dynamics, accelerating translational research.
Creative Biolabs offers GRM8-tuned regulatory T cells development services. Tregs modified to overexpress GRM8 via lentiviral transduction show enhanced immunosuppressive activity in autoimmune encephalomyelitis models. Flow cytometry analyses reveal a 30% increase in IL-10 production, correlating with reduced neuroinflammation. Partner with Creative Biolabs to access advanced ex vivo cell modification platforms for scalable Treg manufacturing.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
