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Hepatitis B Virus (HBV) Virus-Like Particles (VLPs)

Creative Biolabs is a world-leading provider of high-quality hepatitis B virus (HBV) VLPs products. We are determined to assist our customers’ cutting-edge projects with our elegant VLP products.

VLPs are widely known as empty shells of the virus without genomic materials. They share the same virion structural properties while lacking the ability to infect host cells, which makes VLPs the most efficient and safe candidate for vaccines, antibody development, and delivery systems. Besides that, the application of VLPs also demonstrated great potential in a wide range of areas, like lipoparticle technology, bioimaging, cell targeting.

HBV is a member of the Hepadnaviridae family. The HBV particle is composed of an outer lipid envelope and an icosahedral nucleocapsid core. The nucleocapsid encloses the viral DNA and a DNA polymerase with reverse transcriptase activity. The outer envelope contains embedded proteins that are responsible for viral binding and entry into host cells. HBV is one of the smallest enveloped animal viruses with a diameter of 42 nm, but HBV has other pleomorphic forms including filamentous and spherical bodies.

Hepatitis B Virus (HBV) Virus-like Particles (VLPs)

HBV is a non-retroviral virus and has a very complicated replication process. 1) Attachment. The virus invades into the host cell by binding to a receptor on the surface and then enters to cells by clathrin-dependent endocytosis. 2) Penetration. The virus then releases the DNA and core proteins by fusing with the host cell's membrane. 3) Uncoating. It is reported that the capsid is transported to the nuclear pore depend on microtubules. After dissociating from the core proteins, the partially double stranded DNA become fully double stranded and transformed into covalently closed circular DNA (cccDNA) which conducts as a template for four viral mRNAs. 4) Replication. Among the four mRNAs, the largest mRNA is used to amplify the new copies of the viral genome, the capsid core protein, and the DNA polymerase. 5) Assembly. After transcription, the four viral transcripts will be processed additionally and form progeny virions which will release from the cell and infect cells to produce even more copies. 6) Release. The long mRNA will be transported back to the cytoplasm to synthesizes DNA via virion P protein depend on its reverse transcriptase activity.

HBV VLPs can be typically used for:


Creative Biolabs now provides unparalleled VLPs construction service and in-house VLPs products derived from various virus families. We are confident in tailoring our customers the most satisfactory VLP-related assistance using our well-established platforms:


With years of experience in different VLPs construction, our scientists have developed a comprehensive portfolio of VLP products including HIV VLP, HPV VLP, CA16 VLP, EV71 VLP, poliovirus VLP, polyomaviruses VLP, AAV VLP, bacteriophage Qβ VLP, Zika VLP, etc. We look forward to working with both industrial and academic customers and facilitating their VLP projects with our elegant products and services. Please feel free to inquire us for further discussions.

References

  1. Dupinay T, Gheit T, Roques P, et al. (2013). Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca fascicularis from Mauritius Island. Hepatology, 58(5), 1610-1620.
  2. Schwalbe M, Ohlenschläger O, Marchanka A, et al. (2008). Solution structure of stem-loop α of the hepatitis B virus post-transcriptional regulatory element. Nucleic acids research, 36(5), 1681-1689.
  3. Hassan M M, Li D, El-Deeb A S, et al. (2008). Association between hepatitis B virus and pancreatic cancer. Journal of Clinical Oncology, 26(28), 4557-4562.



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