Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Histamine receptor H2 |
| Gene Name | HRH2 |
| Uniprot | P25021 (Human); P97292 (Mouse) |
| Synonym | H2R; HH2R; gastric receptor 1; gastric receptor I |
| Background | Histamine H2 receptor (H2R or HRH2), alternatively known as Gastric receptor I, is an integral membrane protein, in human is encoded by the HRH2 gene. It is recognized as a histamine receptor belonging to the family 1 of G protein-coupled receptors and is predominantly expressed in gastric parietal cells, on vascular smooth muscle, neutrophils, in the heart, and in the central nervous system. HRH2 is positively coupled to adenylate cyclase via Gs, and It is a potent stimulant of cAMP production. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX182 | NativeExtract™ Human HRH2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| Please for more products or customization | ||||
S*m: Creative Biolabs has truly outdone itself with their protein. It is of the highest quality and has exceeded my expectations in terms of performance. The team was very professional and provided excellent customer service throughout the entire process.
08/ Jul/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene editing services. This is a powerful tool for genome engineering. It uses RNA-guided DNA recognition to induce double-strand breaks (DSBs) in the target DNA sequence, and then achieves a range of DNA modifications through DNA repair mechanisms. This method can be used to precisely edit the HRH2 gene to study its function or correct disease-related mutations.
Creative Biolabs offers conditional knockout services. It is used to create conditional knockout mice models. A targeting vector containing loxp sites flanking the ATG start codon of the Hrh2 gene and a neomycin resistance gene is constructed. The vector is then electroporated into embryonic stem (ES) cells, and positively targeted ES cell clones are microinjected into blastocysts to generate chimeric mice. This method allows for the study of HRH2's function in specific cell types and tissues.
Creative Biolabs offers physical delivery methods development services, like ultrasound and hydrodynamic high-pressure injection. Ultrasound-mediated gene transfer uses ultrasound waves to create pores in the cell membrane, allowing therapeutic DNA to enter cells. This method is non-invasive, highly efficient, and has a favorable safety profile. Hydrodynamic high-pressure injection involves the rapid injection of a large volume of plasmid DNA to deliver genes into target tissues.
Creative Biolabs offers comprehensive and innovative services to drive the development of HRH2 cell therapy. Please for more services.
Creative Biolabs offers the generation of HRH2-overexpressing cell lines services. Using genetic engineering techniques, cell lines can be created that overexpress the HRH2 receptor. This can be done by transfecting cells with a plasmid containing the HRH2 gene under the control of a strong promoter. Such cell lines can be used to study the effects of HRH2 signaling in a controlled environment and to screen for potential therapeutic agents that modulate HRH2 activity.
Creative Biolabs offers 3D co-culture Models development services. 3D co-culture systems can more closely mimic the in vivo environment. These models can include HRH2-expressing cells embedded in a matrix with other relevant cell types, allowing for the study of cell-cell interactions and signaling pathways in a more physiologically relevant context.
Creative Biolabs offers phenotypic screening services. Phenotypic screening involves observing the overall effects of a treatment on HRH2-expressing cells, such as changes in morphology, migration, or differentiation. This approach can identify compounds or genetic modifications that have a broad impact on cell behavior, which may be relevant for therapeutic applications.
Based on our extensive experience and excellent expertise, scientists in Creative Biolabs are proud to provide flexible membrane protein preparation services in order to ensure greater prediction of success for your studies. Please feel free to for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
