Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Histamine receptor H3 |
| Gene Name | HRH3 |
| Uniprot | Q9Y5N1 (Human); P58406 (Mouse) |
| Synonym | HH3R; GPCR97; G protein-coupled receptor 97; H3R |
| Background | Histamine H3 receptor (H3R or HRH3), is an integral membrane protein which in human is encoded by HRH3 gene. It is recognized as a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. H3Rs are primarily expressed in the central nervous system and to a lesser extent the peripheral nervous system. The gene sequence for H3Rs expresses only about 22% and 20% homology with H1Rs and H2Rs respectively. Among all the four histamine receptors, H3R is distinguished for its almost exclusive expression in the nervous system and the large variety of isoforms generated by alternative splicing of the corresponding mRNA. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX363 | NativeExtract™ Human HRH3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3579K | MemDX™ Membrane Protein Human HRH3 (Histamine receptor H3) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
L**e: The website was user-friendly, making it easy to navigate and find the exact protein I needed for my research.
12/Aug/2023
D*n: hey were very responsive to my inquiries, providing detailed information and guidance whenever I needed it. Their team is knowledgeable and genuinely committed to helping customers succeed in their research endeavors.
08/ Oct/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers siRNA knockdown services. The targeted, transient attenuation of HRH3 gene expression within cellular systems is a frequently employed strategy, achievable through the de novo design and subsequent synthesis of specific small interfering RNA (siRNA) oligonucleotides. The introduction of these custom-synthesized siRNAs into the target cells is commonly facilitated by established lipid-based transfection reagents. Following transfection, rigorous validation of the achieved knockdown efficiency becomes paramount. Consequently, the extent of HRH3 mRNA depletion is typically quantified utilizing quantitative real-time polymerase chain reaction (qPCR), while the corresponding reduction in HRH3 protein abundance is subsequently ascertained via Western blot analysis.
Creative Biolabs offers gene analysis services. Comprehensive sequence analysis of the HRH3 gene locus serves as a crucial methodology for identifying single nucleotide polymorphisms (SNPs). Intriguingly, these discrete genetic variations are sometimes postulated to exhibit associations with a range of human pathological conditions; multiple sclerosis, for instance, represents one such disease where these links have been investigated. Consequently, the rigorous functional characterization of any identified HRH3 SNPs is of considerable scientific interest.
Creative Biolabs offers comprehensive and innovative services to drive the development of HRH3 cell therapy. Please for more services.
Creative Biolabs offers CCK-8 assay services. Investigating the potential modulatory effects of pharmacological agents targeting the HRH3—be they antagonists or agonists—on overall cellular health is a common research objective; the impact on cell viability, specifically, can be quantitatively assessed using established methodologies such as the CCK-8 assay. The fundamental procedure for this assay involves the systematic exposure of cultured cell populations to a range of defined concentrations of the investigational compounds.
Creative Biolabs offers migration and invasion assay services. Elucidating the functional contribution of the HRH3 to fundamental cellular processes such as motility and invasion remains an important avenue of inquiry; the receptor's involvement in these dynamic behaviors is frequently investigated using well-established in vitro methodologies, including wound-healing assays for assessing collective cell migration to probe invasive capacity through an extracellular matrix surrogate.
As one of the world's top CROs, Creative Biolabs has worked hard in the field of membrane protein preparation to support membrane protein studies. We can provide the largest and most diverse portfolio of standard and custom professional membrane protein preparation services. Please feel free to for experienced technical support.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
