Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | 5-hydroxytryptamine receptor 1A |
| Gene Name | HTR1A |
| Uniprot | P08908 (Human); Q64264 (Mouse) |
| Synonym | G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1; 5-HT1a receptor; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; guanine nucleotide-binding regulatory protein-coupled receptor |
| Background | 5-hydroxytryptamine receptor 1A (5-HT-1A or 5-HT1A), which in human is encoded by HTR1A gene, is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that mediates inhibitory neurotransmission, coupled to the Gi protein. HTR1A has been found in several tissues of the central nervous system, including cerebral cortex, hippocampus, amygdala, septum, and raphe nucleus in high densities, while low amounts also exist in the basal ganglia and thalamus. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX352 | NativeExtract™ Human HTR1A Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3560K |
MemDX™ Membrane Protein Human HTR1A Expressed in vitro E.coli expression system, Full Length |
E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
With our advanced cell line construction platform and extensive experience, we offer you high-quality and highly stable membrane protein stable cell lines to support your research and drug development.
| CAT# | Product Name | Target Species | Host Cell |
| S01YF-1022-KX587 | MemDX™ Human FLAG tagged HTR1A HEK293T Cell Line, Calcium flux assay | Human | HEK293T |
| Please for more products or customization | |||
J**n: I recently contacted Creative Biolabs for HTR1A production and was extremely impressed with their professionalism. They answered all my questions promptly and ensured I was satisfied with the plan.
11/ Jun/2023
M***a: Their team was very responsible and provided excellent guidance. They were very attentive to my requirements and delivered on their promises.
28/ Jul/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers transcription factor regulation services. The expression of the 5-HT1A receptor is understood to be governed by the activity of specific transcription factors. Among these, deformed epidermal autoregulatory factor 1 (Deaf1) has been identified as a key modulator, exhibiting a sophisticated, spatially distinct regulatory mechanism. Specifically, Deaf1 actively represses the transcription of 5-HT1A auto-receptors within the serotonergic neurons of the raphe nuclei. Conversely, in cortical regions, Deaf1 serves to enhance the expression of 5-HT1A heteroreceptors. The development of gene therapy strategies aimed at either activating Deaf1 or augmenting its endogenous induction is an area of active investigation.
Creative Biolabs offers epigenetic modification services. The epigenetic landscape of the HTR1A, particularly the methylation status of its promoter region, is a critical determinant of its transcriptional output. It is hypothesized that a combinatorial therapeutic strategy, involving the co-administration of HTR1A receptor agonists with such demethylating compounds, might significantly augment treatment efficacy. This approach could perhaps offer enhanced therapeutic benefits in diverse and complex pathological conditions, speculatively including major depressive disorder and certain malignancies.
Creative Biolabs offers siRNA and RNA interference services. Targeted gene silencing, mediated through the endogenous RNA interference pathway, presents novel therapeutic possibilities in neuroscience. The application of small interfering RNAs (siRNAs) to specifically downregulate 5-HT1A auto-receptor messenger RNA (mRNA), for instance, emerges as a particularly compelling strategy.
Creative Biolabs offers comprehensive and innovative services to drive the development of HTR1A cell therapy. Please for more services.
Creative Biolabs offers reporter cell line development services. This process involves the introduction of genetically encoded reporters—for instance, those encoding fluorescent proteins—via sophisticated genome editing techniques, ensuring these reporter cassettes are placed under the stringent transcriptional control of endogenous HTR1A cis-regulatory elements. Such meticulously constructed cellular platforms are then envisaged to function as highly sensitive analytical tools.
Creative Biolabs offers induced pluripotent stem cells (iPSCs) development services. A crucial research avenue involves the derivation of induced pluripotent stem cells (iPSCs) from patient cohorts specifically selected for harboring known polymorphisms within the HTR1A gene or for diagnoses of related neurological or psychiatric disorders. Following this, the meticulously guided differentiation of these patient-specific iPSCs into disease-relevant cell types—preeminently neuronal populations implicated in serotonergic signaling or other affected neural circuits—becomes paramount.
Creative Biolabs offers behavioral assay services. The ultimate functional validation of HTR1A-targeted cellular or gene-based therapeutic strategies critically hinges upon rigorous behavioral interrogation within appropriate preclinical animal models. Such investigations would necessarily encompass the systematic evaluation of complex behavioral repertoires. For instance, meticulous assessments might focus on quantifiable alterations in anxiety-related paradigms, established indices of depressive-like states, or nuanced measures of social engagement and interaction, after the administration of the HTR1A-focused intervention, be it through direct cell engraftment or sophisticated gene delivery modalities aimed at modulating HTR1A expression or function.
With the world's broadest range of knowledge in membrane proteins, Creative Biolabs applies its expertise in a variety of membrane protein studies. In complement to our regular membrane protein preparation service, we also provide custom services based on the requirements of the clients to meet the specific demand. Please feel free to for professional technical support.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
