Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | 5-hydroxytryptamine receptor 1D |
| Gene Name | HTR1D |
| Uniprot | P28221 (Human); Q61224 (Mouse) |
| Synonym | HTRL; RDC4; HT1DA; 5-HT1D; HTR1DA; 5-HT-1D; 5-HT-1D-alpha; 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; serotonin 1D alpha receptor; serotonin receptor 1D |
| Background | 5-hydroxytryptamine receptor 1D, alternatively called serotonin receptor 1D, is encoded by HTR1D gene in human. It is one of the subtypes for serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT), and belongs to the G protein-coupled receptor (GPCR) family. HTR1D is predominantly expressed in the basal ganglia, hippocampus, cortex, spinal cord, and vascular smooth muscle cells, but also in the dorsal raphe and locus coeruleus. The HTR1D has 63% overall structural homology with the HTR1B and a 77% amino acid sequence homology in the seven-transmembrane domains. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX350 | NativeExtract™ Human HTR1D Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3498K | MemDX™ Membrane Protein Human HTR1D Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0530X | MemDX™ Membrane Protein Human HTR1D (5-hydroxytryptamine receptor 1D) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX4193K | MemDX™ Membrane Protein Human HTR1D Expressed in Mammalian cell expression system, Partial (1-38aa) | Mammalian cell | Partial | N/A |
| MPX4172K | MemDX™ Membrane Protein Human HTR1D Expressed in Yeast, Partial (1-38aa) | Yeast | Partial | N/A |
| MPX4199K | MemDX™ Membrane Protein Human HTR1D Expressed in E.coli, Partial (1-38aa) | E.coli | Partial | N/A |
| Please for more products or customization | ||||
Z*e: I recently purchased the HTR1D protein from Creative Biolabs, and I am delighted with my purchase. The protein arrived in perfect condition and was of the highest quality.
18/ Jun/2023
L**e: The technical support team was very helpful in answering my questions and providing guidance. The protein was highly pure and worked perfectly for my research needs. I am very impressed with the overall service and will continue to choose Creative Biolabs for my future purchases.
09/ Nov/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers gene expression analysis services. To ascertain the transcriptional activity of the HTR1D gene, quantitative reverse transcription polymerase chain reaction (qRT-PCR) is extensively employed—a methodology esteemed for its sensitivity and specificity. The experimental workflow typically initiates with the isolation of total ribonucleic acid (RNA) from pertinent biological sources, such as tissue specimens or cultured cells, a process accomplished by applying suitable extraction reagents.
Creative Biolabs offers signal pathway analysis services. An expanding body of research indicates that the HTR1D exerts considerable regulatory influence over the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. This intracellular cascade is of paramount importance, playing well-documented roles in governing fundamental cellular processes such as survival, proliferation, and the complex phenomenon of therapeutic resistance. To investigate the molecular mechanisms through which HTR1D modulates this critical pathway, Western blot analysis is a commonly employed and powerful technique. This immunodetection method allows for the sensitive determination of the phosphorylation status of key protein effectors within the PI3K/Akt axis.
Creative Biolabs offers comprehensive and innovative services to drive the development of HTR1D cell therapy. Please for more services.
Creative Biolabs offers stable cell line generation services. To generate cellular models for sustained investigation, the establishment of stable cell lines that constitutively express the HTR1D is often pursued through the strategic application of viral transduction methodologies. Specifically, lentiviral or retroviral vectors serve as highly efficient vehicles for this purpose; these systems are engineered to deliver the HTR1D coding sequence and facilitate its integration into the chromosomal DNA of the target host cells.
Creative Biolabs offers immune compatibility testing services. Given the burgeoning field of cell-based therapeutics, a rigorous evaluation of the host immunological response to cells genetically modified with the HTR1D constitutes a critical step in their preclinical and clinical development pipeline. Indeed, anticipating and characterizing the immunogenicity of such HTR1D-engineered cellular products is of paramount concern for ensuring both safety and efficacy.
Creative Biolabs offers surface marker analysis services. For the comprehensive characterization of cell populations genetically engineered to express the HTR1D, flow cytometry emerges as an indispensable analytical modality. This powerful technique is routinely implemented for the high-throughput identification and meticulous monitoring of diverse cell surface markers, thereby enabling a detailed immunophenotypic fingerprint of the HTR1D-modified cells.
As a reliable partner of the top global pharma companies and research agencies, Creative Biolabs applies its expertise in professional membrane protein preparation of demanded formats by all sorts of strategies, with the world's broadest range of knowledge in this area. Please feel free to for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
