Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | 5-hydroxytryptamine receptor 2C |
| Gene Name | HTR2C |
| Uniprot | P28335 (Human); P34968 (Mouse) |
| Synonym | HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor |
| Background | 5-hydroxytryptamine receptor 2C (HTR2C), alternatively called serotonin receptor 2C, is a G protein-coupled receptor (GPCR) and belongs to the 5-HT2 receptor subfamily which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). HTR2C is encoded by HTR2C gene in human and is coupled to Gq/G11 and mediates excitatory neurotransmission. HTR2C receptors are primarily found in the choroid plexus, and also expressed on epithelial cells lining the ventricles. This receptor exists as a homodimer at the cell surface. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX345 | NativeExtract™ Human HTR2C Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPVLP-020 | MemDX™ Recombinant Human 5-HT2C Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX4062K | MemDX™ Membrane Protein Human HTR2C Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
T***or: Good quality HTR2C protein with solid activity in our experiments. Packaging was secure, but delivery took slightly longer than expected.
08/Dec/2023
A***y: Fast shipping and great communication. A trusted supplier for recombinant proteins!
25/Aug/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers editing-directed therapies development services. The full-length RNA transcript of the HTR2C gene possesses an inherent capacity to form intricate intramolecular double-stranded RNA (dsRNA) loops. These specific secondary structural motifs appear to serve as pivotal facilitators, promoting RNA editing events catalyzed by adenosine deaminases acting on RNA (ADAR) proteins. Consequently, the targeted disruption of these aforementioned RNA secondary structures, perhaps through the judicious introduction of a specifically engineered RNA-binding peptide, could conceivably present novel therapeutic avenues. This strategy, centered on the modulation of RNA editing, may therefore pave the way for the development of future, precisely directed clinical interventions.
Creative Biolabs offers DNA methylation analysis services. Genomic DNA was meticulously isolated from the biological samples. Subsequent to extraction, this isolated DNA was subjected to a sodium bisulfite conversion procedure. This chemical modification was performed with the precise objective of enabling the determination of site-specific CpG methylation patterns within both the promoter region and other designated genomic loci of the HTR2C gene. Following bisulfite treatment, quantitative assessment of methylation levels was achieved. This advanced molecular technique permits the precise quantification of cytosine methylation at individual CpG dinucleotides, thereby offering invaluable insights into the complex epigenetic mechanisms that potentially govern the transcriptional regulation of HTR2C gene expression.
Creative Biolabs offers comprehensive and innovative services to drive the development of HTR2C cell therapy. Please for more services.
Creative Biolabs offers cell-cell contact and signaling research services. The intricate role of HTR2C in mediating cell-cell contact and subsequent intercellular signaling warrants thorough investigation. This can be achieved through the establishment of diverse co-culture systems, specifically designed to incorporate various cell types. These functional assessments might include, for example, the measurement of neurotransmitter release dynamics or the evaluation of neurotransmitter reuptake efficiency, thereby providing a comprehensive understanding of HTR2C's involvement in these critical cellular interactions.
Creative Biolabs offers cell transplantation research services. Investigation into the therapeutic potential of cell-based interventions warrants comprehensive exploration, particularly through the transplantation of cells endogenously expressing HTR2C or its genetically modified variants into established animal models of pertinent pathologies. Following transplantation, it becomes imperative to meticulously monitor several critical parameters: the long-term survival of the engrafted cellular population, their successful integration into the host neural circuitry, and, crucially, their functional impact on the manifestation and progression of disease-associated symptoms.
Creative Biolabs offers cell-derived extracellular vesicles (EVs) services. The potential utility of EVs, particularly those endogenously derived from cells expressing HTR2C, warrants rigorous investigation as a novel therapeutic modality. These vesicles, which serve as natural carriers, are inherently capable of encapsulating a diverse repertoire of signaling molecules; this cargo may encompass HTR2C itself or, perhaps more compellingly, its critical downstream effector molecules. Upon targeted delivery to specific tissues, these EVs could potentially modulate a range of cellular functions, thereby influencing various pathological processes.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
