HTR4 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of HTR4

Protein Name	5-hydroxytryptamine receptor 4
Gene Name	HTR4
Uniprot	Q13639 (Human); P97288 (Mouse)
Synonym	5-HT4; 5-HT4R; 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled; 5-hydroxytryptamine receptor 4 transcript variant b2; 5-hydroxytryptamine receptor 4 transcript variant b3; cardiac 5-HT4 receptor
Background	5-hydroxytryptamine receptor 4 (HTR4), alternatively called serotonin receptor 4, is a G protein-coupled receptor (GPCR) that is identified as one of the several different receptors for 5-hydroxytryptamine (serotonin). HTR4 is encoded by HTR4 gene in human and is expressed in the alimentary tract, urinary bladder, heart, and adrenal gland as well as the central nervous system (CNS). And particularly in the CNS, HTR4 is found in the putamen, caudate nucleus, nucleus accumbens, globus pallidus, and substantia nigra, and to a lesser extent in the neocortex, raphe, pontine nuclei, and some areas of the thalamus.

HTR4 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX344	NativeExtract™ Human HTR4 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MPX3516K	MemDX™ Membrane Protein Human HTR4 Expressed in vitro E.coli expression system, Full Length of Mature Protein	E.coli cell-free	Full length	Detergent
MP0534X	MemDX™ Membrane Protein Human HTR4 (5-hydroxytryptamine receptor 4) for Antibody Discovery	Wheat germ cell-free	Full length	N/A
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Customer Reviews

L*e: Perfect for our assays. Reliable supplier—will order again!

18/Nov/2023

L**e: Good product performance, but delivery was slightly delayed. Detailed COA provided. Recommended for research use.

17/Sep/2024

Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

HTR4 Drug Discovery and Development

HTR4 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-HTR4 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

HTR4 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Selection of Vectors

Creative Biolabs offers vector development services. The selection of viral vectors for gene delivery applications necessitates careful consideration, with a particular emphasis on their intrinsic gene transfer efficiency and the fidelity of expression within target tissues. Among the prevalent choices, adeno-associated virus (AAV) and lentivirus vectors exhibit notable advantages. AAV vectors are frequently employed due to their comparatively low immunogenicity and their remarkable capacity to transduce both actively dividing and quiescent, non-dividing cellular populations. Conversely, lentiviral vectors offer a distinct benefit; their inherent ability to mediate stable integration of the transferred gene into the host cell's genome may prove particularly advantageous for achieving sustained, long-term expression profiles, a desirable characteristic for numerous therapeutic strategies.

Tissue-Specific Promoters and miRNA Targeting

Creative Biolabs offers tissue-specific promoters and miRNA targeting services. To achieve precise spatial control over the expression of the HTR4 gene, it is imperative to employ tissue-specific promoters, thereby restricting its transcription solely to the intended cellular populations. Complementing this transcriptional regulation, an additional layer of control can be introduced at the post-transcriptional level. This involves incorporating specific microRNA (miRNA) target sequences within the 3' untranslated region (UTR) of the HTR4 messenger RNA (mRNA). These strategically positioned sequences are designed to be complementary to endogenous miRNAs that are robustly and specifically expressed in non-target tissues. This refined approach may significantly contribute to minimizing potential adverse effects and enhancing the overall safety profile of the therapeutic intervention.

HTR4 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of HTR4 cell therapy. Please inquire with us for more services.

Gene Editing

Creative Biolabs offers gene editing services. Investigators might consider employing advanced techniques to engineer the selective incapacitation of the HTR4 gene within highly defined cellular populations or anatomical structures. Such meticulous genetic perturbations would permit a rigorous examination of the ensuing alterations in neuronal functionality, perhaps revealing novel insights into synaptic plasticity or even broader implications for cognitive processes. Subsequently, comprehensive phenotyping of these genetically modified organisms—or perhaps even isolated cellular constructs—would be indispensable for thoroughly assessing the behavioral and cellular consequences attributable to the engineered absence of this particular receptor.

Knockout Models

Creative Biolabs offers knockout models development services. Genetically engineered murine models serve as indispensable tools for dissecting the intricate functions of specific genes within complex biological systems. In this investigative context, the generation of conditional knockout (cKO) mouse lines offers a remarkably precise methodology for exploring the localized roles of particular gene products. To delineate the contribution of the HTR4 receptor to neural processes, a compelling strategy would involve the creation of such cKO models, wherein the HTR4 gene is ablated in a spatiotemporally controlled manner. It is conceivable that such models could ultimately illuminate previously uncharacterized roles for HTR4 within the complex interplay of neurogenesis and affective states.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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