Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsHydroxy-carboxylic acid (HCA) receptor family consists of three members, HCA1, HCA2, and HCA3, also known as GPR81, GPR109A, andGPR109B, respectively, which are encoded by closely related genes located next to each other on human chromosome 12 and mouse chromosome 5. HCA1 is the phylogeneticallyearliest receptor found in fish.
Fig.1 Regulation of Adipocyte Function through HCA Receptors. (Offermanns, 2017)
The physiological ligands of HCA receptors are key metabolic intermediates whose local and systemic levels reflect specific metabolic states. All three HCA receptors are highly expressed in white and brown adipocytes. It has been shown that the expression of HCA1 and HCA2 increases during differentiation of adipocytes from preadipocytes and after activation of peroxisome proliferator-activated receptor-gamma. Lactic acid activates HCA1 on adipocytes in an autocrine manner. It inhibits lipolysis and thus promotes anabolic effects. Blocking HCA1 can prevent and treat obesity. HCA2 and HCA3 regulate adipocyte lipolysis and immune function under conditions that increase FFA formation by lipolysis. HCA2 agonists that act primarily through immune cell receptors exert antiatherogenic and anti-inflammatory effects. HCA2 is a butyrate receptor and mediates some of the beneficial effects of short-chain fatty acids produced by the intestinal flora. HCA is also important for controlling the metabolism and proliferation of breast cancer cells.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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